Ophiorrhiza

Ophiorrhiza is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.[2][3] So many of Ophiorrhiza species are endemic to certain areas of western Ghats. Species include:

  • Ophiorrhiza acuminata[4]
  • Ophiorrhiza blumeana[5]
  • Ophiorrhiza bracteata[5]
  • Ophiorrhiza cantoniensis
  • Ophiorrhiza carinata
  • Ophiorrhiza caudata[2]
  • Ophiorrhiza dulongensis
  • Ophiorrhiza filistipula
  • Ophiorrhiza japonica
  • Ophiorrhiza kuroiwai[6]
  • Ophiorrhiza liukiuensis[4]
  • Ophiorrhiza longiflora
  • Ophiorrhiza lurida
  • Ophiorrhiza major[5]
  • Ophiorrhiza michelloides[7][8]
  • Ophiorrhiza mungos
  • Ophiorrhiza nutans
  • Ophiorrhiza prostrata[1]
  • Ophiorrhiza pumila[4][9]
  • Ophiorrhiza rosea
  • Ophiorrhiza rugosa
  • Ophiorrhiza succirubra

Ophiorrhiza
Ophiorrhiza mungos
Scientific classification
Kingdom:
Plantae
(unranked):
Angiosperms
(unranked):
Eudicots
(unranked):
Asterids
Order:
Gentianales
Family:
Rubiaceae
Genus:
Ophiorrhiza

Species

About 150,[1] see text

References
  1. Beegum, A. S., et al. (2007). Organogenesis from leaf and internode explants of Ophiorrhiza prostrata, an anticancer drug (camptothecin) producing plant. Electronic Journal of Biotechnology 10:1.
  2. Joseph, G. and J. P. Joseph. Rediscovery of Ophiorrhiza caudata (Rubiaceae) from the Western Ghats of Kerala. Rheedia 19 45.
  3. Viraporn, V., et al. (2010). Correlation of camptothecin-producing ability and phylogenetic relationship in the genus Ophiorrhiza. Planta Med. in pub.
  4. Sirikantaramas, S., et al. (2008). Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants. PNAS 105:18 6782.
  5. Arbain, D, et al. (1998). Unusual indole alkaloids from Ophiorrhiza blumeana Korth. J. Chem. Soc., Perkin Trans 1.
  6. Asano, T., et al. (2004). Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O. kuroiwai. Plant Biotechnology 21:4 275.
  7. Chu, F., et al. (2006). Taxonomic Status of Ophiorrhiza michelloides (Masam.) X. R. Lo (Rubiaceae) in Taiwan. Taiwania 51:2 143.
  8. Nakamura, K., et al. (2006). Phylogenetic systematics of the monotypic genus Hayataella (Rubiaceae) endemic to Taiwan. Journal of Plant Research 119:657–661.
  9. Nakamura, K., et al. (2006). Homostyly and autogamy in Ophiorrhiza pumila (Rubiaceae) in the Ryukyu Archipelago. Journal of Japanese Botany 81:113–120.


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