OTUD7B

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.[5][6]

OTUD7B
Identifiers
Aliases	OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748 MGI: 2654703 HomoloGene: 10624 GeneCards: OTUD7B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,937,812 bp[1] End 150,010,726 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,104,527 bp[2] End 96,161,129 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • cysteine-type peptidase activity • zinc ion binding • metal ion binding • peptidase activity • K63-linked polyubiquitin modification-dependent protein binding • GO:0001948 protein binding • thiol-dependent ubiquitin-specific protease activity • hydrolase activity • Lys48-specific deubiquitinase activity • thiol-dependent ubiquitinyl hydrolase activity Cellular component • cytoplasm • cell nucleus • cytosol Biological process • mucosal immune response • negative regulation of protein localization to nucleus • protein K48-linked deubiquitination • protein deubiquitination involved in ubiquitin-dependent protein catabolic process • immune system process • negative regulation of transcription from RNA polymerase II promoter • negative regulation of I-kappaB kinase/NF-kappaB signaling • proteolysis • negative regulation of interleukin-8 production • protein K63-linked deubiquitination • immune response • protein deubiquitination • protein K11-linked deubiquitination • adaptive immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56957	229603
Ensembl	ENSG00000264522	ENSMUSG00000038495
UniProt	Q6GQQ9	B2RUR8
RefSeq (mRNA)	NM_020205	NM_001025613 NM_001025614
RefSeq (protein)	NP_064590	NP_001020784 NP_001020785
Location (UCSC)	Chr 1: 149.94 – 150.01 Mb	Chr 3: 96.1 – 96.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000264522 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038495 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Journal of Biochemistry. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
6. "Entrez Gene: OTUD7B OTU domain containing 7B".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC 1224040. PMID 14748687.
• Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry. 278 (25): 23180–6. doi:10.1074/jbc.M301863200. PMID 12682062.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.