NUPL1

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.[5][6]

NUP58
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JO7, 4JO9, 4JQ5, 5IJN, 5IJO
Identifiers
Aliases	NUP58, PRO2463, NUPL1, NUP45, nucleoporin 58kDa, nucleoporin 58
External IDs	OMIM: 607615 MGI: 1919094 HomoloGene: 40924 GeneCards: NUP58
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.13 Start 25,301,556 bp[1] End 25,349,800 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 60,205,282 bp[2] End 60,251,507 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nuclear localization sequence binding • GO:0005487 structural constituent of nuclear pore Cellular component • nuclear membrane • nuclear envelope • membrane • cell nucleus • nuclear pore • macromolecular complex • host cell Biological process • mRNA transport • protein heterotetramerization • protein heterooligomerization • nucleocytoplasmic transport • regulation of protein import into nucleus • protein transport • GO:0022415 viral process • protein homooligomerization • mRNA export from nucleus • protein import into nucleus • protein heterotrimerization • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • regulation of gene silencing by miRNA • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9818	71844
Ensembl	ENSG00000139496	ENSMUSG00000114797
UniProt	Q9BVL2	Q8R332
RefSeq (mRNA)	NM_001008564 NM_001008565 NM_014089	NM_170591 NM_001362439 NM_001362440
RefSeq (protein)	NP_001008564 NP_054808	NP_733479 NP_001349368 NP_001349369
Location (UCSC)	Chr 13: 25.3 – 25.35 Mb	Chr 14: 60.21 – 60.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC).

All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000139496 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000114797 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
6. "Entrez Gene: NUPL1 nucleoporin like 1".

Further reading

• Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.