NUCKS1

Nuclear ubiquitous casein and cyclin-dependent kinases substrate is a protein that in humans is encoded by the NUCKS1 gene.[5][6]

NUCKS1
Identifiers
Aliases	NUCKS1, NUCKS, JC7, nuclear casein kinase and cyclin-dependent kinase substrate 1, nuclear casein kinase and cyclin dependent kinase substrate 1
External IDs	OMIM: 611912 MGI: 1934811 HomoloGene: 23377 GeneCards: NUCKS1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,712,822 bp[1] End 205,750,182 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 131,910,534 bp[2] End 131,936,321 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • chromatin binding • double-stranded DNA binding • single-stranded DNA binding • RNA binding Cellular component • cytoplasm • cell nucleus • nuclear chromatin • chromatin • nucleolus Biological process • positive regulation of insulin receptor signaling pathway • transcription from RNA polymerase II promoter • glucose homeostasis • positive regulation of transcription from RNA polymerase II promoter • interstrand cross-link repair • regulation of DNA strand elongation • cellular response to X-ray • regulation of DNA replication • gene conversion • double-strand break repair via homologous recombination • regulation of transcription from RNA polymerase II promoter • replication fork processing • cellular glucose homeostasis • chromatin organization • regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64710	98415
Ensembl	ENSG00000069275	ENSMUSG00000026434
UniProt	Q9H1E3	Q80XU3
RefSeq (mRNA)	NM_022731	NM_001145804 NM_175294
RefSeq (protein)	NP_073568	NP_001139276 NP_780503
Location (UCSC)	Chr 1: 205.71 – 205.75 Mb	Chr 1: 131.91 – 131.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000069275 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026434 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ostvold AC, Norum JH, Mathiesen S, Wanvik B, Sefland I, Grundt K (Apr 2001). "Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo". Eur J Biochem. 268 (8): 2430–40. doi:10.1046/j.1432-1327.2001.02120.x. PMID 11298763.
6. "Entrez Gene: NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Thompson HG, Harris JW, Wold BJ, et al. (2003). "Identification and confirmation of a module of coexpressed genes". Genome Res. 12 (10): 1517–22. doi:10.1101/gr.418402. PMC 187523. PMID 12368243.
• Grundt K, Skjeldal L, Anthonsen HW, et al. (2002). "A putative DNA-binding domain in the NUCKS protein". Arch. Biochem. Biophys. 407 (2): 168–75. doi:10.1016/S0003-9861(02)00513-1. PMID 12413487.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Grundt K, Haga IV, Aleporou-Marinou V, et al. (2004). "Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species". Biochem. Biophys. Res. Commun. 323 (3): 796–801. doi:10.1016/j.bbrc.2004.08.153. PMID 15381070.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Grundt K, Haga IV, Huitfeldt HS, Ostvold AC (2007). "Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS". Biochim. Biophys. Acta. 1773 (9): 1398–406. doi:10.1016/j.bbamcr.2007.05.013. PMID 17604136.