NRCAM

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.[5][6]

NRCAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEN, 1UEY
Identifiers
Aliases	NRCAM, neuronal cell adhesion molecule
External IDs	OMIM: 601581 MGI: 104750 HomoloGene: 21041 GeneCards: NRCAM
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.1 Start 108,147,623 bp[1] End 108,456,717 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 B2|12 20.71 cM Start 44,328,885 bp[2] End 44,601,964 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein binding involved in heterotypic cell-cell adhesion • ankyrin binding Cellular component • integral component of membrane • cell projection • membrane • cell membrane • synapse • integral component of plasma membrane • extracellular region • axon • neuron projection • axon initial segment • external side of plasma membrane • glutamatergic synapse • integral component of postsynaptic membrane • integral component of postsynaptic density membrane Biological process • protein localization • clustering of voltage-gated sodium channels • regulation of neuron projection development • regulation of axon extension • axonogenesis • heterotypic cell-cell adhesion • neuron migration • central nervous system development • cell adhesion • neuronal action potential propagation • angiogenesis • positive regulation of neuron differentiation • synapse assembly • axonal fasciculation • retinal ganglion cell axon guidance • axon guidance • cell-cell adhesion • regulation of postsynapse organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4897	319504
Ensembl	ENSG00000091129	ENSMUSG00000020598
UniProt	Q92823	Q810U4
RefSeq (mRNA)	NM_001037132 NM_001037133 NM_001193582 NM_001193583 NM_001193584 NM_005010	NM_001146031 NM_176930
RefSeq (protein)	NP_001032209 NP_001180511 NP_001180512 NP_001180513 NP_005001 NP_001358048 NP_001358051 NP_001358052 NP_001358053 NP_001358054 NP_001358055 NP_001358056 NP_001358057 NP_001358058 NP_001358059 NP_001358060 NP_001358061 NP_001358062 NP_001358063 NP_001358064 NP_001358065 NP_001358066 NP_001358067 NP_001358068 NP_001358069 NP_001358070 NP_001358071 NP_001358072 NP_001358073 NP_001358074 NP_001358075 NP_001358076 NP_001358077 NP_001358078 NP_001358079 NP_001358080 NP_001358081 NP_001358082 NP_001358083 NP_001358084 NP_001358085 NP_001358086 NP_001358087 NP_001358088 NP_001358089 NP_001358090 NP_001358091 NP_001358092 NP_001358093 NP_001358094 NP_001358095 NP_001358096 NP_001358097 NP_001358098 NP_001358099 NP_001358100 NP_001358101 NP_001358102 NP_001358103 NP_001358104 NP_001358105 NP_001358106 NP_001358107 NP_001358108 NP_001358109 NP_001358110 NP_001358111	NP_001139503 NP_795904
Location (UCSC)	Chr 7: 108.15 – 108.46 Mb	Chr 12: 44.33 – 44.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism[7] and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000091129 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020598 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lane RP, Chen XN, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ (Dec 1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. 35 (3): 456–65. doi:10.1006/geno.1996.0385. PMID 8812479.
6. "Entrez Gene: NRCAM neuronal cell adhesion molecule".
7. Marui T, Funatogawa I, Koishi S, et al. (2008). "Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism". Int J Neuropsychopharmacol. 12 (1): 1–10. doi:10.1017/S1461145708009127. PMID 18664314.

Further reading

• Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and receptor functions". Cell Tissue Res. 290 (2): 423–8. doi:10.1007/s004410050949. PMID 9321706.
• Sakurai T, Lustig M, Nativ M, et al. (1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". J. Cell Biol. 136 (4): 907–18. doi:10.1083/jcb.136.4.907. PMC 2132488. PMID 9049255.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Wang B, Williams H, Du JS, et al. (1998). "Alternative splicing of human NrCAM in neural and nonneural tissues". Mol. Cell. Neurosci. 10 (5–6): 287–95. doi:10.1006/mcne.1997.0658. PMID 9604207.
• Moré MI, Kirsch FP, Rathjen FG (2001). "Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation". J. Cell Biol. 154 (1): 187–96. doi:10.1083/jcb.200104038. PMC 2196853. PMID 11449000.
• Dry K, Kenwrick S, Rosenthal A, Platzer M (2001). "The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily". Gene. 273 (1): 115–22. doi:10.1016/S0378-1119(01)00493-0. PMID 11483367.
• Jenkins SM, Bennett V (2002). "Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments". J. Cell Biol. 155 (5): 739–46. doi:10.1083/jcb.200109026. PMC 2150881. PMID 11724816.
• Aitkenhead M, Wang SJ, Nakatsu MN, et al. (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM". Microvasc. Res. 63 (2): 159–71. doi:10.1006/mvre.2001.2380. PMID 11866539.
• Pavlou O, Theodorakis K, Falk J, et al. (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Mol. Cell. Neurosci. 20 (3): 367–81. doi:10.1006/mcne.2002.1105. PMID 12139915.
• Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M, et al. (2002). "Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis". Genes Dev. 16 (16): 2058–72. doi:10.1101/gad.227502. PMC 186445. PMID 12183361.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Custer AW, Kazarinova-Noyes K, Sakurai T, et al. (2003). "The role of the ankyrin-binding protein NrCAM in node of Ranvier formation". J. Neurosci. 23 (31): 10032–9. doi:10.1523/JNEUROSCI.23-31-10032.2003. PMC 6740847. PMID 14602817.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hutcheson HB, Olson LM, Bradford Y, et al. (2004). "Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes". BMC Med. Genet. 5: 12. doi:10.1186/1471-2350-5-12. PMC 420465. PMID 15128462.
• Bonora E, Lamb JA, Barnby G, et al. (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi:10.1038/sj.ejhg.5201315. PMID 15523497.
• Ishiguro H, Liu QR, Gong JP, et al. (2006). "NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice". Neuropsychopharmacology. 31 (3): 572–84. doi:10.1038/sj.npp.1300855. PMID 16123759.