NDFIP2

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.[5][6][7]

NDFIP2
Identifiers
Aliases	NDFIP2, N4WBP5A, Nedd4 family interacting protein 2
External IDs	OMIM: 610041 MGI: 1923523 HomoloGene: 12636 GeneCards: NDFIP2
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.1 Start 79,481,124 bp[1] End 79,556,075 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E2.3 Start 105,258,573 bp[2] End 105,309,298 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • GO:0001948 protein binding • WW domain binding Cellular component • cytoplasm • integral component of membrane • endosome • Golgi apparatus • multivesicular body membrane • intracellular membrane-bounded organelle • membrane • Golgi membrane • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • endosome membrane Biological process • negative regulation of gene expression • negative regulation of protein transport • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of protein ubiquitination • negative regulation of transporter activity • signal transduction • vacuolar transport • metal ion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54602	76273
Ensembl	ENSG00000102471	ENSMUSG00000053253
UniProt	Q9NV92	Q91ZP6
RefSeq (mRNA)	NM_001161407 NM_019080	NM_001190989 NM_029561
RefSeq (protein)	NP_001154879 NP_061953	n/a
Location (UCSC)	Chr 13: 79.48 – 79.56 Mb	Chr 14: 105.26 – 105.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NDFIP2 has been shown to interact with NEDD4.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000102471 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053253 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
6. Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem. 277 (33): 29406–16. doi:10.1074/jbc.M203018200. PMID 12050153.
7. "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".
8. Cristillo, Anthony D; Nie Linghu; Macri Mirtha J; Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. ISSN 0021-9258. PMID 12796489.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Cristillo AD, Nie L, Macri MJ, Bierer BE (2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi:10.1074/jbc.M304723200. PMID 12796489.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Shearwin-Whyatt LM, Brown DL, Wylie FG, et al. (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking". J. Cell Sci. 117 (Pt 16): 3679–89. doi:10.1242/jcs.01212. PMID 15252135.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.