CHRNA9

Neuronal acetylcholine receptor subunit alpha-9, also known as nAChRα9, is a protein that in humans is encoded by the CHRNA9 gene.[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

CHRNA9
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCHRNA9, HSA243342, NACHRA9, cholinergic receptor nicotinic alpha 9 subunit
External IDsOMIM: 605116 MGI: 1202403 HomoloGene: 9729 GeneCards: CHRNA9
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p14Start40,335,333 bp[1]
End40,355,217 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55584

231252

Ensembl

ENSG00000174343

ENSMUSG00000029205

UniProt

Q9UGM1

n/a

RefSeq (mRNA)

NM_017581

NM_001081104

RefSeq (protein)

NP_060051

n/a

Location (UCSC)Chr 4: 40.34 – 40.36 MbChr 5: 65.93 – 65.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

α9 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell function and is expressed in both the inner and outer hair cells (OHCs) of the adult cochlea, although expression levels in adult inner hair cells is low. The activation of the alpha9/10 nAChR is via olivocochlear activity, represented by cholinergic efferent synaptic terminals originating from the superior olive region of the brainstem. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.[5]

Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000174343 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029205 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9".
  6. Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–17884. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.