ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.[5][6]

ADAMTS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADAMTS1, C3-C5, METH1, ADAM metallopeptidase with thrombospondin type 1 motif 1
External IDsOMIM: 605174 MGI: 109249 HomoloGene: 21381 GeneCards: ADAMTS1
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q21.3Start26,835,755 bp[1]
End26,845,409 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9510

11504

Ensembl

ENSG00000154734

ENSMUSG00000022893

UniProt

Q9UHI8

P97857

RefSeq (mRNA)

NM_006988

NM_009621

RefSeq (protein)

NP_008919

NP_033751

Location (UCSC)Chr 21: 26.84 – 26.85 MbChr 16: 85.79 – 85.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.[6]

Interactions

ADAMTS1 has been shown to interact with Vascular endothelial growth factor A.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000154734 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022893 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (September 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
  6. "Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1".
  7. Luque A, Carpizo DR, Iruela-Arispe ML (June 2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165". J. Biol. Chem. 278 (26): 23656–65. doi:10.1074/jbc.M212964200. PMID 12716911.

Further reading



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