Marta Zlatic

Marta Zlatic is a Croatian neuroscientist who is group leader at the Medical Research Council. Her current research considers how neural circuits generate behaviour.[1] In 2020 she was awarded the Royal Society Francis Crick Medal.

Marta Zlatic
Born
Croatia
Alma materUniversity of Cambridge
University of Zagreb
Scientific career
InstitutionsUniversity of Cambridge
Janelia Research Campus
ThesisEstablishment of connectivity in the embryonic central nervous system of Drosophila. (2004)

Early life and education

Zlatic is from Zagreb, Croatia.[2][3] She has said that growing up she had excellent Latin and Greek teachers.[4] She was awarded a full scholarship to study natural sciences at the Trinity College, Cambridge. During her summer holidays from Cambridge Zlatic studied linguistics and Russian at the University of Zagreb. Alongside her studies, Zlatic was involved with the Cambridge theatre scene, taking part in Greek tragedies and Shakespeare's plays.[2] As an undergraduate student Zlatic attended the lectures of Mike Bate, where he discussed the neural circuits of fruit flies. She enjoyed the lectures so much that she applied for a postgraduate degree.[2] During her doctoral research Zlatic looked at the development of neurons in drosophila.[2] As the nervous system starts to form, neurons start to produce axons and dendrites.[2] Zlatic showed that sensory neurons, which allow for sight, sound, pain and touch, look for particular locations in the nervous system using positional cues. After earning her doctorate, Zlatic was awarded a postdoctoral fellowship at the University of Cambridge which allowed her to travel internationally and study the assembly of neural circuits.[4]

Research and career

In 2009 Zlatic started her independent career at the Janelia Research Campus.[3][5] At Janelia she learnt about the genetic tools used to manipulate the types of neurons in drosophila.[4] Zlatic has dedicated her career to the study of the nervous system, in particular the positional cue known as the slit protein which controls how sensory neuron axons start and stop growing. She showed that slit proteins control branching along the mediolateral axis but not the dorsoventral axis, indicating that there are positional cues in three-dimensions.

Zlatic is interested the complex functions of the human brain, including language and communication. She has studied the brains of different species; including drosophila and maggots.[2] She made use of electron microscopy to map the entire drosophila connectome, and studies the strengths of the connections between neurons that are structurally connected.[6] By investigating the activity of these neurons it is possible to associate particular patterns with the formation of memories.

Awards and honours

Personal life

Zlatic is fluent in several languages, including Croatian, English, German, French, Russian, Spanish, Ancient Greek, and Latin.[2] Alongside her enthusiasm for languages and neuroscience, Zlatic is an actress.[2] She is married to neuroscientist Albert Cardona.[4]

Selected publications
  • Fosque, Benjamin F.; Sun, Yi; Dana, Hod; Yang, Chao-Tsung; Ohyama, Tomoko; Tadross, Michael R.; Patel, Ronak; Zlatic, Marta; Kim, Douglas S.; Ahrens, Misha B.; Jayaraman, Vivek (2015-02-13). "Labeling of active neural circuits in vivo with designed calcium integrators". Science. 347 (6223): 755–760. doi:10.1126/science.1260922. ISSN 0036-8075. PMID 25678659.
  • Ohyama, Tomoko; Schneider-Mizell, Casey M.; Fetter, Richard D.; Aleman, Javier Valdes; Franconville, Romain; Rivera-Alba, Marta; Mensh, Brett D.; Branson, Kristin M.; Simpson, Julie H.; Truman, James W.; Cardona, Albert (2015). "A multilevel multimodal circuit enhances action selection in Drosophila". Nature. 520 (7549): 633–639. doi:10.1038/nature14297. ISSN 1476-4687.
  • Eichler, Katharina; Li, Feng; Litwin-Kumar, Ashok; Park, Youngser; Andrade, Ingrid; Schneider-Mizell, Casey M.; Saumweber, Timo; Huser, Annina; Eschbach, Claire; Gerber, Bertram; Fetter, Richard D. (2017). "The complete connectome of a learning and memory centre in an insect brain". Nature. 548 (7666): 175–182. doi:10.1038/nature23455. ISSN 1476-4687.

References
  1. "Francis Crick Medal and Lecture | Royal Society". royalsociety.org. Retrieved 2020-08-05.
  2. "Marta Zlatic | Janelia Research Campus". www.janelia.org. Retrieved 2020-08-05.
  3. "MARTA ZLATIC – FKNE". Retrieved 2020-08-05.
  4. Gewin, Virginia (2014). "Turning point: Marta Zlatic". Nature. 509 (7499): 251–251. doi:10.1038/nj7499-251a. ISSN 1476-4687.
  5. "Marta Zlatic". HHMI.org. Retrieved 2020-08-05.
  6. Smith,Nature, Kerri. "How to Map the Circuits That Define Us". Scientific American. Retrieved 2020-08-06.
  7. Administrator (2017-03-13). "Dr Marta Zlatic is awarded the Eric Kandel Young Neuroscientist Prize 2017". www.zoo.cam.ac.uk. Retrieved 2020-08-05.
  8. "Royal Society announces 2020 winners of prestigious medals and awards | Royal Society". royalsociety.org. Retrieved 2020-08-05.
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