MTCH2

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[4][5][6][7]

MTCH2
Identifiers
Aliases	MTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
External IDs	OMIM: 613221 MGI: 1929260 HomoloGene: 8645 GeneCards: MTCH2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 47,617,315 bp[1] End 47,642,607 bp[1]
Orthologs
Species	Human	Mouse
Entrez	23788	56428
Ensembl	ENSG00000109919 ENSG00000285121	ENSMUSG00000027282
UniProt	Q9Y6C9	Q791V5
RefSeq (mRNA)	NM_014342 NM_001317231 NM_001317232 NM_001317233	NM_019758 NM_001317241 NM_001317242 NM_001317243 NM_001317244
RefSeq (protein)	NP_001304160 NP_001304161 NP_001304162 NP_055157	NP_001304170 NP_001304171 NP_001304172 NP_001304173 NP_062732
Location (UCSC)	Chr 11: 47.62 – 47.64 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.[8]

Clinical significance

MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.[8]

Variants of the MTCH2 gene may be associated with obesity.[9] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.[8]

See also

• Mitochondrial carrier

References

1. ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Mol. Cell. Biol. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861.
5. Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". J. Bioenerg. Biomembr. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168.
6. Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis. 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157.
7. Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLOS Genet. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107.
8. Gross A (2016). "BCL-2 family proteins as regulators of mitochondria metabolism". Biochimica et Biophysica Acta. 1857 (8): 1243–1246. doi:10.1016/j.bbabio.2016.01.017. PMID 26827940.
9. Renström F, Payne F, Nordström A, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.

Further reading

• Yerushalmi GM, Leibowitz-Amit R, Shaharabany M, Tsarfaty I (2002). "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization". Neoplasia. 4 (6): 510–22. doi:10.1038/sj.neo.7900272. PMC 1503665. PMID 12407445.
• Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring). 18 (6): 1212–1217. doi:10.1038/oby.2009.413. PMID 19910938.
• Albers M, Kranz H, Kober I, et al. (2005). "Automated yeast two-hybrid screening for nuclear receptor-interacting proteins". Mol. Cell. Proteomics. 4 (2): 205–13. doi:10.1074/mcp.M400169-MCP200. PMID 15604093.
• Willer CJ, Speliotes EK, Loos RJ, et al. (2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 25–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261.
• Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". Am. J. Clin. Nutr. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171.
• Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". Am. J. Clin. Nutr. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• He M, Cornelis MC, Franks PW, et al. (2010). "Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus". Arterioscler. Thromb. Vasc. Biol. 30 (2): 327–32. doi:10.1161/ATVBAHA.109.196196. PMC 3061473. PMID 19910641.
• Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". J. Hum. Genet. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340.