MSC (gene)

Musculin is a protein that in humans is encoded by the MSC gene.[5][6][7]

MSC
Identifiers
AliasesMSC, ABF-1, ABF1, MYOR, bHLHa22, musculin
External IDsOMIM: 603628 MGI: 1333884 HomoloGene: 3738 GeneCards: MSC
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q13.3Start71,841,549 bp[1]
End71,844,468 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9242

17681

Ensembl

ENSG00000178860

ENSMUSG00000025930

UniProt

O60682

O88940

RefSeq (mRNA)

NM_005098

NM_010827
NM_001360810

RefSeq (protein)

NP_005089

NP_034957
NP_001347739

Location (UCSC)Chr 8: 71.84 – 71.84 MbChr 1: 14.75 – 14.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000178860 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025930 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C (Jun 1998). "Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes". Mol Cell Biol. 18 (6): 3130–9. doi:10.1128/mcb.18.6.3130. PMC 108895. PMID 9584154.
  6. Robb L, Brodnicki T, Copeland NG, Gilbert DJ, Jenkins NA, Harvey RP (May 1999). "Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1". Genomics. 57 (2): 318–9. doi:10.1006/geno.1999.5764. PMID 10198176.
  7. "Entrez Gene: MSC musculin (activated B-cell factor-1)".

Further reading


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