MIER1

Mesoderm induction early response protein 1 is a protein that in humans is encoded by the MIER1 gene.[5][6][7]

MIER1
Identifiers
Aliases	MIER1, ER1, MI-ER1, MIER1 transcriptional regulator
External IDs	OMIM: 616848 MGI: 1918398 HomoloGene: 136176 GeneCards: MIER1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 66,924,895 bp[1] End 66,988,619 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 103,114,390 bp[2] End 103,165,754 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • signal transducer activity • histone deacetylase activity • histone deacetylase binding Cellular component • cytoplasm • transcriptional repressor complex • nucleoplasm • cell nucleus Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of transcription, DNA-templated • positive regulation of chromatin silencing • transcription, DNA-templated • signal transduction • histone deacetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57708	71148
Ensembl	ENSG00000198160	ENSMUSG00000028522
UniProt	Q8N108	Q5UAK0
RefSeq (mRNA)	NM_001077700 NM_001077701 NM_001077702 NM_001077703 NM_001077704 NM_001146110 NM_001146111 NM_001146112 NM_001146113 NM_001278215 NM_020948 NM_001350530	NM_001039081 NM_001286221 NM_001286222 NM_001286223 NM_027696
RefSeq (protein)	NP_001071168 NP_001071169 NP_001071170 NP_001071171 NP_001071172 NP_001139582 NP_001139583 NP_001139584 NP_001139585 NP_001265144 NP_065999 NP_001337459	NP_001034170 NP_001273150 NP_001273151 NP_001273152 NP_081972
Location (UCSC)	Chr 1: 66.92 – 66.99 Mb	Chr 4: 103.11 – 103.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MIER1 has been shown to interact with HDAC1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198160 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028522 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL (Jul 2002). "Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization". Gene. 295 (1): 79–88. doi:10.1016/S0378-1119(02)00823-5. PMID 12242014.
6. Ding Z, Gillespie LL, Paterno GD (Jan 2003). "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain". Molecular and Cellular Biology. 23 (1): 250–8. doi:10.1128/MCB.23.1.250-258.2003. PMC 140656. PMID 12482978.
7. "Entrez Gene: MIER1 mesoderm induction early response 1 homolog (Xenopus laevis)".

Further reading

• Paterno GD, Mercer FC, Chayter JJ, Yang X, Robb JD, Gillespie LL (Nov 1998). "Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines". Gene. 222 (1): 77–82. doi:10.1016/S0378-1119(98)00473-9. PMID 9813250.
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ding Z, Gillespie LL, Mercer FC, Paterno GD (Jul 2004). "The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter". The Journal of Biological Chemistry. 279 (27): 28009–16. doi:10.1074/jbc.M403793200. PMID 15117948.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.