MICAL3

Microtubule-associated monoxygenase, calponin and LIM domain containing 3, also known as MICAL3, is a human gene.[5]

MICAL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D88
Identifiers
Aliases	MICAL3, MICAL-3, microtubule associated monooxygenase, calponin and LIM domain containing 3
External IDs	OMIM: 608882 MGI: 2442733 HomoloGene: 85288 GeneCards: MICAL3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 17,787,649 bp[1] End 18,024,561 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F1 Start 120,931,707 bp[2] End 121,130,999 bp[2]
Gene ontology Molecular function • monooxygenase activity • oxidoreductase activity • actin binding • FAD binding • metal ion binding • GO:0001948 protein binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • Rab GTPase binding Cellular component • cell membrane • cytoskeleton • cell nucleus • nucleoplasm • cytoplasm • cytosol • spindle • cell cortex • midbody • cell projection Biological process • actin filament depolymerization • oxidation-reduction process • cytoskeleton organization • exocytosis • cell cycle • cell division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57553	194401
Ensembl	ENSG00000243156	ENSMUSG00000051586
UniProt	Q7RTP6	Q8CJ19
RefSeq (mRNA)	NM_001122731 NM_001136004 NM_015241 NM_020793	NM_001270475 NM_153396
RefSeq (protein)	NP_001116203 NP_001129476 NP_056056	NP_001257404 NP_700445
Location (UCSC)	Chr 22: 17.79 – 18.02 Mb	Chr 6: 120.93 – 121.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000243156 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051586 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MICAL3 microtubule associated monoxygenase, calponin and LIM domain containing 3".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Terman JR, Mao T, Pasterkamp RJ, et al. (2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.