METTL2B

Methyltransferase-like protein 2B is an enzyme that in humans is encoded by the METTL2B gene.[3][4]

METTL2B
Identifiers
Aliases	METTL2B, METL, METTL2, METTL2A, PSENIP1, methyltransferase like 2B
External IDs	OMIM: 607846 HomoloGene: 130696 GeneCards: METTL2B
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.1 Start 128,476,729 bp[1] End 128,506,602 bp[1]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55798	n/a
Ensembl	ENSG00000165055	n/a
UniProt	Q6P1Q9	n/a
RefSeq (mRNA)	NM_018396	n/a
RefSeq (protein)	NP_060866	n/a
Location (UCSC)	Chr 7: 128.48 – 128.51 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000165055 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Zhang SX, Guo Y, Boulianne GL (Dec 2001). "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins". Gene. 280 (1–2): 135–44. doi:10.1016/S0378-1119(01)00770-3. PMID 11738826.
4. "Entrez Gene: METTL2B methyltransferase like 2B".

Further reading

• Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.