METTL1

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.[5][6]

METTL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CKK
Identifiers
Aliases	METTL1, C12orf1, TRM8, TRMT8, YDL201w, methyltransferase like 1
External IDs	OMIM: 604466 MGI: 1339986 HomoloGene: 3918 GeneCards: METTL1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 57,768,471 bp[1] End 57,772,119 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,041,414 bp[2] End 127,046,365 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • tRNA binding • tRNA (guanine-N7-)-methyltransferase activity • GO:0001948 protein binding • RNA binding Cellular component • tRNA methyltransferase complex • nucleolus • cell nucleus • nucleoplasm • cytosol Biological process • methylation • tRNA modification • tRNA processing • tRNA (guanine-N7)-methylation • tRNA methylation • RNA (guanine-N7)-methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4234	17299
Ensembl	ENSG00000037897	ENSMUSG00000006732
UniProt	Q9UBP6	Q9Z120
RefSeq (mRNA)	NM_005371 NM_023032 NM_023033	NM_010792
RefSeq (protein)	NP_005362 NP_075422	NP_034922
Location (UCSC)	Chr 12: 57.77 – 57.77 Mb	Chr 10: 127.04 – 127.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.[6]

See also

• 7-Methylguanosine

References

1. GRCh38: Ensembl release 89: ENSG00000037897 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006732 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER (Aug 1999). "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation". Genomics. 57 (3): 424–8. doi:10.1006/geno.1999.5780. PMID 10329009.
6. "Entrez Gene: METTL1 methyltransferase like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.