MEMO1

Mediator of cell motility 1 is a protein that in humans is encoded by the MEMO1 gene.[5]

MEMO1
Identifiers
Aliases	MEMO1, C2orf4, MEMO, NS5ATP7, CGI-27, mediator of cell motility 1
External IDs	OMIM: 611786 MGI: 1924140 HomoloGene: 6272 GeneCards: MEMO1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.3 Start 31,865,060 bp[1] End 32,011,230 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E2 Start 74,199,036 bp[2] End 74,295,521 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell nucleus • cytosol Biological process • regulation of microtubule-based process • regulation of cell motility Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51072	76890
Ensembl	ENSG00000162959	ENSMUSG00000058704
UniProt	Q9Y316	Q91VH6
RefSeq (mRNA)	NM_001137602 NM_015955 NM_001301833 NM_001301852	NM_133771
RefSeq (protein)	NP_001131074 NP_001288762 NP_001288781 NP_057039 NP_001358841 NP_001358842 NP_001358843 NP_001358844 NP_001358845 NP_001358846 NP_001358847 NP_001358849 NP_001358850	NP_598532
Location (UCSC)	Chr 2: 31.87 – 32.01 Mb	Chr 17: 74.2 – 74.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000162959 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058704 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mediator of cell motility 1".

Further reading

• Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (March 2009). "Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration". Journal of Cell Science. 122 (Pt 6): 787–97. doi:10.1242/jcs.032094. PMID 19223396.
• Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A (June 2004). "Memo mediates ErbB2-driven cell motility". Nature Cell Biology. 6 (6): 515–22. doi:10.1038/ncb1134. PMID 15156151.
• Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (November 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.
• Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ (February 2008). "Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site". The Journal of Biological Chemistry. 283 (5): 2734–40. doi:10.1074/jbc.M703523200. PMID 18045866.
• Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (June 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A (November 2008). "Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells". The Journal of Cell Biology. 183 (3): 401–8. doi:10.1083/jcb.200805107. PMC 2575782. PMID 18955552.