MED7

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.[5][6]

MED7
Identifiers
Aliases	MED7, ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs	OMIM: 605045 MGI: 1913463 HomoloGene: 3153 GeneCards: MED7
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 157,137,424 bp[1] End 157,159,019 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 46,436,925 bp[2] End 46,442,721 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • GO:0001104 transcription cofactor activity • GO:0001948 protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cellular component • mediator complex • cell nucleus • transcription factor complex • nucleoplasm • ubiquitin ligase complex • nuclear body Biological process • regulation of transcription from RNA polymerase II promoter • stem cell population maintenance • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • protein ubiquitination • transcription, DNA-templated • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9443	66213
Ensembl	ENSG00000155868	ENSMUSG00000020397
UniProt	O43513	Q9CZB6
RefSeq (mRNA)	NM_004270 NM_001100816	NM_001104530 NM_001104556 NM_001104557 NM_025426
RefSeq (protein)	NP_001094286 NP_004261	NP_001098000 NP_001098026 NP_001098027 NP_079702
Location (UCSC)	Chr 5: 157.14 – 157.16 Mb	Chr 11: 46.44 – 46.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000155868 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020397 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
6. "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137–42. doi:10.1073/pnas.96.13.7137. PMC 22029. PMID 10377381.
• Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
• Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8538–43. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
• Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain". Genes Dev. 12 (1): 45–54. doi:10.1101/gad.12.1.45. PMC 316402. PMID 9420330.