MED19

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene. [5]

MED19
Identifiers
Aliases	MED19, DT2P1G7, LCMR1, MED19AS, mediator complex subunit 19
External IDs	OMIM: 612385 MGI: 1914234 HomoloGene: 14684 GeneCards: MED19
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 57,703,714 bp[1] End 57,712,323 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 D Start 84,678,402 bp[2] End 84,688,215 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • GO:0001104 transcription coregulator activity • transcription factor binding Cellular component • cell nucleus • mediator complex • nuclear body Biological process • regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219541	381379
Ensembl	ENSG00000156603	ENSMUSG00000027080
UniProt	A0JLT2	Q8C1S0
RefSeq (mRNA)	NM_153450 NM_001317078	NM_025885
RefSeq (protein)	NP_001304007 NP_703151	NP_080161
Location (UCSC)	Chr 11: 57.7 – 57.71 Mb	Chr 2: 84.68 – 84.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

See also

• Mediator

References

1. GRCh38: Ensembl release 89: ENSG00000156603 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027080 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mediator complex subunit 19". Retrieved 2018-02-06.

Further reading

• Ding N, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Boyer TG (2009). "MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression". J. Biol. Chem. 284 (5): 2648–56. doi:10.1074/jbc.M806514200. PMC 2631966. PMID 19049968.
• Li LH, He J, Hua D, Guo ZJ, Gao Q (2011). "Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro". Cancer Chemother. Pharmacol. 68 (1): 207–15. doi:10.1007/s00280-010-1468-9. PMID 20890603.
• Chen L, Liang Z, Tian Q, Li C, Ma X, Zhang Y, Yang Z, Wang P, Li Y (2011). "Overexpression of LCMR1 is significantly associated with clinical stage in human NSCLC". J. Exp. Clin. Cancer Res. 30: 18. doi:10.1186/1756-9966-30-18. PMC 3045976. PMID 21306606.
• Zou SW, Ai KX, Wang ZG, Yuan Z, Yan J, Zheng Q (2011). "The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells". Acta Pharmacol. Sin. 32 (3): 354–60. doi:10.1038/aps.2010.223. PMC 4002777. PMID 21372827.
• Zhang H, Jiang H, Wang W, Gong J, Zhang L, Chen Z, Ding Q (2012). "Expression of Med19 in bladder cancer tissues and its role on bladder cancer cell growth". Urol. Oncol. 30 (6): 920–7. doi:10.1016/j.urolonc.2010.10.003. PMID 21478038.
• Sun M, Jiang R, Li JD, Luo SL, Gao HW, Jin CY, Shi DL, Wang CG, Wang B, Zhang XY (2011). "MED19 promotes proliferation and tumorigenesis of lung cancer". Mol. Cell. Biochem. 355 (1–2): 27–33. doi:10.1007/s11010-011-0835-0. PMID 21519921.
• Wang T, Hao L, Feng Y, Wang G, Qin D, Gu G (2011). "Knockdown of MED19 by lentivirus-mediated shRNA in human osteosarcoma cells inhibits cell proliferation by inducing cell cycle arrest in the G0/G1 phase". Oncol. Res. 19 (5): 193–201. doi:10.3727/096504011x12970940207760. PMID 21542455.
• Ji-Fu E, Xing JJ, Hao LQ, Fu CG (2012). "Suppression of lung cancer metastasis-related protein 1 (LCMR1) inhibits the growth of colorectal cancer cells". Mol. Biol. Rep. 39 (4): 3675–81. doi:10.1007/s11033-011-1142-2. PMID 21732059.
• Cui X, Xu D, Lv C, Qu F, He J, Chen M, Liu Y, Gao Y, Che J, Yao Y, Yu H (2011). "Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells". BMB Rep. 44 (8): 547–52. doi:10.5483/bmbrep.2011.44.8.547. PMID 21871180.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.