MED12L

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene. [5]

MED12L
Identifiers
Aliases	MED12L, NOPAR, TNRC11L, TRALP, TRALPUSH, mediator complex subunit 12 like, mediator complex subunit 12L, NIZIDS
External IDs	OMIM: 611318 MGI: 2139916 HomoloGene: 43143 GeneCards: MED12L
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 151,085,697 bp[1] End 151,437,072 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 D Start 59,005,825 bp[2] End 59,318,682 bp[2]
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • beta-catenin binding • GO:0001104 transcription coregulator activity Cellular component • cell nucleus • mediator complex Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116931	329650
Ensembl	ENSG00000144893	ENSMUSG00000056476
UniProt	Q86YW9	Q8BQM9
RefSeq (mRNA)	NM_053002	NM_177855
RefSeq (protein)	NP_443728	NP_808523
Location (UCSC)	Chr 3: 151.09 – 151.44 Mb	Chr 3: 59.01 – 59.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010].

See also

• Mediator

References

1. GRCh38: Ensembl release 89: ENSG00000144893 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056476 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mediator complex subunit 12 like". Retrieved 2018-02-06.

Further reading

• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.