MBOAT5

Lysophospholipid acyltransferase 5 is an enzyme that in humans is encoded by the LPCAT3 gene.[4][5][6][7] It is homologous to other membrane-bound O-acyltransferases.

LPCAT3
Identifiers
Aliases	LPCAT3, C3F, LPCAT, LPLAT 5, LPSAT, MBOAT5, OACT5, nessy, lysophosphatidylcholine acyltransferase 3
External IDs	OMIM: 611950 MGI: 1315211 HomoloGene: 14678 GeneCards: LPCAT3
EC number	2.3.1.23
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,976,185 bp[1] End 7,018,477 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • 1-acylglycerophosphocholine O-acyltransferase activity • transferase activity, transferring acyl groups • 2-acylglycerol-3-phosphate O-acyltransferase activity • 1-acylglycerol-3-phosphate O-acyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • phosphatidylserine acyl-chain remodeling • phosphatidylethanolamine acyl-chain remodeling • phosphatidylcholine acyl-chain remodeling • regulation of plasma lipoprotein particle levels • lipid metabolism • phospholipid biosynthetic process • phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10162	14792
Ensembl	ENSG00000111684	n/a
UniProt	Q6P1A2	Q91V01
RefSeq (mRNA)	NM_005768	NM_145130
RefSeq (protein)	NP_005759	NP_660112
Location (UCSC)	Chr 12: 6.98 – 7.02 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000111684 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (Sep 1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.
5. Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (May 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
6. Zhao Y, Chen YQ, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G (Mar 2008). "Identification and characterization of a major liver lysophosphatidylcholine acyltransferase". J Biol Chem. 283 (13): 8258–65. doi:10.1074/jbc.M710422200. PMID 18195019.
7. "Entrez Gene: MBOAT5 membrane bound O-acyltransferase domain containing 5".

Further reading

• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Maurel-Zaffran C, Chauvet S, Jullien N, et al. (1999). "nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis". Mech. Dev. 86 (1–2): 159–63. doi:10.1016/S0925-4773(99)00105-7. PMID 10446276.

External links

• LPCAT3 human gene location in the UCSC Genome Browser.
• LPCAT3 human gene details in the UCSC Genome Browser.