MAP7

Ensconsin is a protein that in humans is encoded by the MAP7 gene.[5][6]

MAP7
Identifiers
Aliases	MAP7, E-MAP-115, EMAP115, microtubule associated protein 7
External IDs	OMIM: 604108 MGI: 1328328 HomoloGene: 20851 GeneCards: MAP7
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 136,342,281 bp[1] End 136,550,819 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A3|10 9.75 cM Start 20,148,471 bp[2] End 20,281,590 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • structural molecule activity • GO:0001948 protein binding Cellular component • perinuclear region of cytoplasm • cell membrane • basolateral plasma membrane • microtubule • cytoskeleton • membrane • microtubule associated complex • microtubule cytoskeleton • cytoplasm • cytosol • axon Biological process • response to osmotic stress • establishment or maintenance of cell polarity • protein localization to plasma membrane • microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9053	17761
Ensembl	ENSG00000135525	ENSMUSG00000019996
UniProt	Q14244	O88735
RefSeq (mRNA)	NM_001198608 NM_001198609 NM_001198611 NM_001198614 NM_001198615 NM_001198616 NM_001198617 NM_001198618 NM_001198619 NM_003980	NM_001198635 NM_001198636 NM_008635 NM_001358787
RefSeq (protein)	NP_001185537 NP_001185538 NP_001185540 NP_001185543 NP_001185544 NP_001185545 NP_001185546 NP_001185547 NP_001185548 NP_003971	NP_001185564 NP_032661 NP_001345716
Location (UCSC)	Chr 6: 136.34 – 136.55 Mb	Chr 10: 20.15 – 20.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.[6]

Interactions

MAP7 has been shown to interact with TRPV4.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000135525 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019996 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Masson D, Kreis TE (Nov 1993). "Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells". J Cell Biol. 123 (2): 357–71. doi:10.1083/jcb.123.2.357. PMC 2119845. PMID 8408219.
6. "Entrez Gene: MAP7 microtubule-associated protein 7".
7. Suzuki M, Hirao A, Mizuno A (December 2003). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216.

Further reading

• Masson D, Kreis TE (1996). "Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation". J. Cell Biol. 131 (4): 1015–24. doi:10.1083/jcb.131.4.1015. PMC 2200015. PMID 7490279.
• Fabre-Jonca N, Viard I, French LE, Masson D (1999). "Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts". J. Invest. Dermatol. 112 (2): 216–25. doi:10.1046/j.1523-1747.1999.00500.x. PMID 9989799.
• Bulinski JC, Odde DJ, Howell BJ, Salmon TD, Waterman-Storer CM (2002). "Rapid dynamics of the microtubule binding of ensconsin in vivo". J. Cell Sci. 114 (Pt 21): 3885–97. PMID 11719555.
• Penttilä TL, Parvinen M, Paranko J (2004). "Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette". Int. J. Androl. 26 (3): 166–74. doi:10.1046/j.1365-2605.2003.00406.x. PMID 12755995.
• Vanier MT, Deck P, Stutzmann J, Gendry P, Arnold C, Dirrig-Grosch S, Kedinger M, Launay JF (2004). "Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells". Cell Motil. Cytoskeleton. 55 (4): 221–31. doi:10.1002/cm.10124. PMID 12845596.
• Suzuki M, Hirao A, Mizuno A (2004). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216.
• Sood R, Bader PI, Speer MC, Edwards YH, Eddings EM, Blair RT, Hu P, Faruque MU, Robbins CM, Zhang H, Leuders J, Morrison K, Thompson D, Schwartzberg PL, Meltzer PS, Trent JM (2004). "Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis". Cytogenet. Genome Res. 106 (1): 61–7. doi:10.1159/000078563. PMID 15218243.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.