MALL

MAL-like protein is a protein that in humans is encoded by the MALL gene.[5][6]

MALL
Identifiers
Aliases	MALL, BENE, mal, T-cell differentiation protein like, mal, T cell differentiation protein like
External IDs	OMIM: 602022 MGI: 2385152 HomoloGene: 3965 GeneCards: MALL
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 110,083,870 bp[1] End 110,116,022 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 127,704,386 bp[2] End 127,729,932 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • structural constituent of myelin sheath Cellular component • Golgi membrane • clathrin-coated vesicle • cell membrane • membrane • membrane raft • integral component of membrane • cytoplasmic vesicle Biological process • cholesterol homeostasis • membrane raft polarization • protein localization • myelination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7851	228576
Ensembl	ENSG00000144063	ENSMUSG00000027377
UniProt	Q13021	Q91X49
RefSeq (mRNA)	NM_005434 NM_001371559 NM_001371560	NM_145532
RefSeq (protein)	NP_005425 NP_001358488 NP_001358489	NP_663507
Location (UCSC)	Chr 2: 110.08 – 110.12 Mb	Chr 2: 127.7 – 127.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000144063 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027377 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hildebrandt F, Otto E, Rensing C, Nothwang HG, Vollmer M, Adolphs J, Hanusch H, Brandis M (Nov 1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149–53. doi:10.1038/ng1097-149. PMID 9326933.
6. "Entrez Gene: MALL mal, T-cell differentiation protein-like".

Further reading

• Kurdina MI, Denisov LE (1993). "[An evaluation of the efficacy of dispensary care as a method for the active detection of skin melanoma]". Klinicheskaia meditsina. 70 (11–12): 68–70. PMID 1294831.
• Lautner-Rieske A, Thiebe R, Zachau HG (1995). "Searching for non-V kappa transcripts from the human immunoglobulin kappa locus". Gene. 159 (2): 199–202. doi:10.1016/0378-1119(95)00161-X. PMID 7622049.
• Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U (1997). "Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family". Gene. 189 (2): 269–75. doi:10.1016/S0378-1119(96)00861-X. PMID 9168137.
• Saunier S, Calado J, Heilig R, et al. (1998). "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis". Hum. Mol. Genet. 6 (13): 2317–23. doi:10.1093/hmg/6.13.2317. PMID 9361039.
• de Marco MC, Kremer L, Albar JP, et al. (2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells". J. Biol. Chem. 276 (25): 23009–17. doi:10.1074/jbc.M009739200. PMID 11294831.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.