LYVE1

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor.[5] In humans it is encoded by the LYVE1 gene.[6]

LYVE1
Identifiers
AliasesLYVE1, CRSBP-1, HAR, LYVE-1, XLKD1, lymphatic vessel endothelial hyaluronan receptor 1
External IDsOMIM: 605702 MGI: 2136348 HomoloGene: 4868 GeneCards: LYVE1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start10,556,966 bp[1]
End10,611,689 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10894

114332

Ensembl

ENSG00000133800

ENSMUSG00000030787

UniProt

Q9Y5Y7

Q8BHC0

RefSeq (mRNA)

NM_006691

NM_053247

RefSeq (protein)

NP_006682

NP_444477

Location (UCSC)Chr 11: 10.56 – 10.61 MbChr 7: 110.85 – 110.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LYVE1 is a type I integral membrane glycoprotein. It acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.[6] LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, allowing for the isolation of these cells for experimental purposes. The physiological role for this receptor is still the subject of debate, but evolutionary conservation suggests an important role.

Expression of LYVE1 not restricted to lymph vessels but is also observed in normal liver blood sinusoids [7], and embryonic blood vessels [8].

LYVE1 expression is also observed in subset of macrophages.[9] [10] LYVE1 positive macrophages in the meninges of rats are both lymphatic, as well as, alymphatic.[11] In brain dura, the LYVE1+ macrophages were predominantly pleomorphic in morphology, while the cells in the spinal cord were pleomorphic in the cervical dura, while in the thoracal dura the cells were mainly round in morphology. The cells in brain dura were associated with collagen network in meninges, and some nonlymphatic LYVE1+ macrophages contained intracellular collagen. The exact function of these cells is yet unknown.

References

  1. GRCh38: Ensembl release 89: ENSG00000133800 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030787 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, et al. (February 1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". The Journal of Cell Biology. 144 (4): 789–801. doi:10.1083/jcb.144.4.789. PMC 2132933. PMID 10037799.
  6. "LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 [ Homo sapiens (human) ]".
  7. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK (November 2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Research. 61 (22): 8079–84. PMID 11719431.
  8. Gordon EJ, Gale NW, Harvey NL (July 2008). "Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels". Developmental Dynamics. 237 (7): 1901–9. doi:10.1002/dvdy.21605. PMID 18570254.
  9. Lee HW, Qin YX, Kim YM, Park EY, Hwang JS, Huo GH, et al. (February 2011). "Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney". Cell and Tissue Research. 343 (2): 429–44. doi:10.1007/s00441-010-1098-x. PMID 21181199.
  10. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA (April 2007). "Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing". The American Journal of Pathology. 170 (4): 1178–91. doi:10.2353/ajpath.2007.060018. PMC 1829452. PMID 17392158.
  11. Brezovakova V, Jadhav S (January 2020). "Identification of Lyve-1 positive macrophages as resident cells in meninges of rats". The Journal of Comparative Neurology. doi:10.1002/cne.24870. PMID 32003471.

Further reading

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