LUC7L

Putative RNA-binding protein Luc7-like 1 is a protein that in humans is encoded by the LUC7L gene.[5]

LUC7L
Identifiers
Aliases	LUC7L, LUC7-LIKE, LUC7B1, Luc7, SR+89, hLuc7B1, LUC7 like
External IDs	OMIM: 607782 MGI: 1914228 HomoloGene: 100558 GeneCards: LUC7L
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 188,969 bp[1] End 229,463 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 13.09 cM Start 26,252,896 bp[2] End 26,285,504 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RS domain binding • GO:0001948 protein binding • mRNA binding • identical protein binding Cellular component • U1 snRNP • U2-type prespliceosome • cell nucleus Biological process • mRNA splice site selection • negative regulation of striated muscle tissue development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55692	66978
Ensembl	ENSG00000007392	ENSMUSG00000024188
UniProt	Q9NQ29 Q1W6G4	Q9CYI4
RefSeq (mRNA)	NM_018032 NM_201412 NM_001320226 NM_001330420	NM_025881 NM_028190
RefSeq (protein)	NP_001307155 NP_001317349 NP_060502 NP_958815 NP_060502.1 NP_001307155.1	NP_080157 NP_082466
Location (UCSC)	Chr 16: 0.19 – 0.23 Mb	Chr 17: 26.25 – 26.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000007392 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024188 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LUC7L LUC7-like (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Tufarelli C, Frischauf AM, Hardison R, et al. (2001). "Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain". Genomics. 71 (3): 307–14. doi:10.1006/geno.2000.6394. PMID 11170747.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.