LMO1

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.[5][6][7]

LMO1
Identifiers
AliasesLMO1, RBTN1, RHOM1, TTG1, LIM domain only 1
External IDsOMIM: 186921 MGI: 102812 HomoloGene: 48101 GeneCards: LMO1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start8,224,309 bp[1]
End8,268,716 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4004

109594

Ensembl

ENSG00000166407

ENSMUSG00000036111

UniProt

P25800

Q924W9

RefSeq (mRNA)

NM_001270428
NM_002315

NM_001302205
NM_001302206
NM_057173
NM_001382564

RefSeq (protein)

NP_001257357
NP_002306

NP_001289134
NP_001289135
NP_476514
NP_001369493

Location (UCSC)Chr 11: 8.22 – 8.27 MbChr 7: 109.14 – 109.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[7]

Interactions

LMO1 has been shown to interact with GATA3[8][9] and TAL1.[10][11]

References

  1. GRCh38: Ensembl release 89: ENSG00000166407 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036111 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367–71. Bibcode:1991PNAS...88.4367B. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
  6. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599–606. doi:10.1182/blood.V77.3.599.599. PMID 1703797.
  7. "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)".
  8. Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. 18 (12): 6939–50. doi:10.1128/MCB.18.12.6939. ISSN 0270-7306. PMC 109277. PMID 9819382.
  9. Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. ISSN 0021-9258. PMID 9020185.
  10. Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. ISSN 0027-8424. PMC 44657. PMID 8078932.
  11. Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. ISSN 0261-4189. PMC 395422. PMID 7957052.

Further reading

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