LMLN

Leishmanolysin-like (metallopeptidase M8 family) is a protein that in humans is encoded by the LMLN gene.[4]

LMLN
Identifiers
Aliases	LMLN, GP63, INV, IX14, MSP, leishmanolysin like peptidase, LMNL1
External IDs	OMIM: 609380 MGI: 2444736 HomoloGene: 13198 GeneCards: LMLN
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 197,960,200 bp[1] End 198,043,720 bp[1]
Gene ontology Molecular function • peptidase activity • metalloendopeptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding Cellular component • lipid droplet • membrane • focal adhesion • cytoplasm • cytosol Biological process • cell cycle • cell adhesion • proteolysis • cell division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	89782	239833
Ensembl	ENSG00000185621	n/a
UniProt	Q96KR4	Q8BMN4
RefSeq (mRNA)	NM_001136049 NM_033029	NM_172823
RefSeq (protein)	NP_001129521 NP_149018	NP_766411
Location (UCSC)	Chr 3: 197.96 – 198.04 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009].

References

1. GRCh38: Ensembl release 89: ENSG00000185621 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Leishmanolysin-like (metallopeptidase M8 family)".

Further reading

• Cobbe N, Marshall KM, Gururaja Rao S, Chang CW, Di Cara F, Duca E, Vass S, Kassan A, Heck MM (September 2009). "The conserved metalloprotease invadolysin localizes to the surface of lipid droplets". Journal of Cell Science. 122 (Pt 18): 3414–23. doi:10.1242/jcs.044610. PMC 2736869. PMID 19706689.
• McHugh B, Krause SA, Yu B, Deans AM, Heasman S, McLaughlin P, Heck MM (November 2004). "Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration". The Journal of Cell Biology. 167 (4): 673–86. doi:10.1083/jcb.200405155. PMC 2172566. PMID 15557119.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.