LGI2

Leucine-rich repeat LGI family member 2 is a protein that in humans is encoded by the LGI2 gene.[5][6][7]

LGI2
Identifiers
Aliases	LGI2, LGIL2, leucine-rich repeat LGI family member 2, leucine rich repeat LGI family member 2
External IDs	OMIM: 608301 MGI: 2180196 HomoloGene: 10048 GeneCards: LGI2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 24,998,847 bp[1] End 25,030,946 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C1 Start 52,533,517 bp[2] End 52,566,462 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55203	246316
Ensembl	ENSG00000153012	ENSMUSG00000039252
UniProt	Q8N0V4	Q8K4Z0
RefSeq (mRNA)	NM_018176	NM_144945 NM_001310604
RefSeq (protein)	NP_060646	NP_001297533 NP_659194
Location (UCSC)	Chr 4: 25 – 25.03 Mb	Chr 5: 52.53 – 52.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000153012 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039252 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK (May 2002). "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins". FEBS Lett. 519 (1–3): 71–6. doi:10.1016/S0014-5793(02)02713-8. PMID 12023020.
6. Gu W, Gibert Y, Wirth T, Elischer A, Bloch W, Meyer A, Steinlein OK, Begemann G (Oct 2005). "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders". Mol Biol Evol. 22 (11): 2209–16. doi:10.1093/molbev/msi214. PMID 16014869.
7. "Entrez Gene: LGI2 leucine-rich repeat LGI family, member 2".

Further reading

• Staub E, Pérez-Tur J, Siebert R, et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. doi:10.1016/S0968-0004(02)02163-1. PMID 12217514.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Scheel H, Tomiuk S, Hofmann K (2003). "A common protein interaction domain links two recently identified epilepsy genes". Hum. Mol. Genet. 11 (15): 1757–62. doi:10.1093/hmg/11.15.1757. PMID 12095917.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519.