LEPREL2

Prolyl 3-hydroxylase 3 is an enzyme that in humans is encoded by the LEPREL2 gene.[5][6]

P3H3
Identifiers
Aliases	P3H3, GRCB, HSU47926, LEPREL2, prolyl 3-hydroxylase 3
External IDs	OMIM: 610342 MGI: 1315208 HomoloGene: 8401 GeneCards: P3H3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,828,407 bp[1] End 6,839,847 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,841,089 bp[2] End 124,857,752 bp[2]
Gene ontology Molecular function • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • L-ascorbic acid binding • dioxygenase activity • iron ion binding • oxidoreductase activity • metal ion binding • procollagen-proline 3-dioxygenase activity Cellular component • endoplasmic reticulum • catalytic complex Biological process • negative regulation of cell proliferation • peptidyl-proline hydroxylation • oxidation-reduction process • collagen metabolic process • peptidyl-lysine hydroxylation • collagen biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10536	14789
Ensembl	ENSG00000110811	ENSMUSG00000023191
UniProt	Q8IVL6	Q8CG70
RefSeq (mRNA)	NM_014262	NM_013534
RefSeq (protein)	NP_055077	NP_038562
Location (UCSC)	Chr 12: 6.83 – 6.84 Mb	Chr 6: 124.84 – 124.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000110811 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023191 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jarnum S, Kjellman C, Darabi A, Nilsson I, Edvardsen K, Aman P (Apr 2004). "LEPREL1, a novel ER and Golgi resident member of the Leprecan family". Biochem Biophys Res Commun. 317 (2): 342–51. doi:10.1016/j.bbrc.2004.03.060. PMID 15063763.
6. "Entrez Gene: LEPREL2 leprecan-like 2".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vranka JA, Sakai LY, Bächinger HP (2004). "Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes". J. Biol. Chem. 279 (22): 23615–21. doi:10.1074/jbc.M312807200. PMID 15044469.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
• Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.