LARP4

La-related protein 4 is a protein that in humans is encoded by the LARP4 gene.[4][5] LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.[6]

LARP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQK, 3PKN
Identifiers
Aliases	LARP4, PP13296, La ribonucleoprotein domain family member 4
External IDs	MGI: 2443114 HomoloGene: 19173 GeneCards: LARP4
Gene location (Mouse) Chr. Chromosome 15 (mouse)[1] Band 15|15 F1 Start 99,970,065 bp[1] End 100,016,358 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • poly(A) binding • RNA binding Cellular component • membrane • polysome • cytoplasmic stress granule • cytosolic small ribosomal subunit • cytoplasm • cytosol Biological process • regulation of cell morphogenesis • cytoskeleton organization • positive regulation of translation • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113251	207214
Ensembl	n/a	ENSMUSG00000023025
UniProt	Q71RC2	Q8BWW4
RefSeq (mRNA)	NM_001170803 NM_001170804 NM_001170808 NM_052879 NM_199188 NM_199190 NM_001330415	NM_001024526 NM_001080948 NM_001284521 NM_001284522 NM_001284523
RefSeq (protein)	NP_001164274 NP_001164275 NP_001164279 NP_001317344 NP_443111 NP_954658 NP_954660 NP_001339233 NP_001339234 NP_001339235 NP_001339236 NP_001339237 NP_001339238 NP_001339239 NP_001339240 NP_001339241 NP_001339242 NP_001339243 NP_001339244 NP_001339245 NP_001339246 NP_001339247 NP_001339248 NP_001339249 NP_001339250 NP_001339251 NP_001339252 NP_001339253 NP_001339254 NP_001339255	NP_001019697 NP_001074417 NP_001271450 NP_001271451 NP_001271452
Location (UCSC)	n/a	Chr 15: 99.97 – 100.02 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

LARP4 is known to regulate cancer cell migration and invasion by altering cell shape.[7] It is also reported to be a glioma tumor suppressor.[8]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000023025 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
5. "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
6. Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
7. Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
8. Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

Further reading

• Stavraka C, Blagden S (October 2015). "The La-Related Proteins, a Family with Connections to Cancer". Biomolecules. 5 (4): 2701–22. doi:10.3390/biom5042701. PMC 4693254. PMID 26501340.
• Kralovics R, Skoda RC (January 2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Reviews. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
• Puigdecanet E, Espinet B, Villa O, Florensa L, Besses C, Serrano S, Solé F (May 2006). "Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia". Cancer Genetics and Cytogenetics. 167 (1): 39–42. doi:10.1016/j.cancergencyto.2005.08.016. PMID 16682284.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.