LANCL1

LanC like 1 is a protein that in humans is encoded by the LANCL1 gene. [5]

LANCL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E6U, 3E73
Identifiers
Aliases	LANCL1, GPR69A, p40, LanC like 1
External IDs	OMIM: 604155 MGI: 1336997 HomoloGene: 4417 GeneCards: LANCL1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q34 Start 210,431,249 bp[1] End 210,477,652 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C3 Start 67,000,517 bp[2] End 67,038,872 bp[2]
Gene ontology Molecular function • SH3 domain binding • low-density lipoprotein particle receptor binding • zinc ion binding • GO:0001948 protein binding • G-protein coupled receptor activity • metal ion binding • glutathione binding • catalytic activity • glutathione transferase activity • transferase activity Cellular component • cytoplasm • integral component of plasma membrane • membrane • cell membrane Biological process • G-protein coupled receptor signaling pathway • regulation of neuron apoptotic process • regulation of oxidative stress-induced neuron death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10314	14768
Ensembl	ENSG00000115365	ENSMUSG00000026000
UniProt	O43813	O89112
RefSeq (mRNA)	NM_001136574 NM_001136575 NM_006055	NM_001190984 NM_001190985 NM_021295
RefSeq (protein)	NP_001130046 NP_001130047 NP_006046	NP_001177913 NP_001177914 NP_067270
Location (UCSC)	Chr 2: 210.43 – 210.48 Mb	Chr 1: 67 – 67.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

1. GRCh38: Ensembl release 89: ENSG00000115365 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026000 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LanC like 1". Retrieved 2016-04-20.

Further reading

• Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, Rao Z, Zhang XC (2009). "Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione". Genes Dev. 23 (12): 1387–92. doi:10.1101/gad.1789209. PMC 2701572. PMID 19528316.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.