Late endosomal/lysosomal adaptor, mapk and mtor activator 1

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 is a protein that in humans is encoded by the LAMTOR1 gene. [5]

LAMTOR1
Identifiers
Aliases	LAMTOR1, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
External IDs	OMIM: 613510 MGI: 1913758 HomoloGene: 9909 GeneCards: LAMTOR1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,085,895 bp[1] End 72,103,297 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,905,904 bp[2] End 101,926,675 bp[2]
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • GO:0001948 protein binding • GO:0032947 molecular adaptor activity • GTPase binding Cellular component • endosome • late endosome membrane • membrane • Ragulator complex • lysosomal membrane • membrane raft • lysosome • extracellular exosome • cell membrane • azurophil granule membrane • specific granule membrane • ficolin-1-rich granule membrane Biological process • regulation of cholesterol import • regulation of cholesterol efflux • endosome organization • cellular protein localization • lysosome localization • cell cycle arrest • cellular response to amino acid stimulus • cholesterol homeostasis • regulation of receptor recycling • lysosome organization • regulation of cholesterol esterification • positive regulation of TOR signaling • positive regulation of MAPK cascade • neutrophil degranulation • regulation of macroautophagy • regulation of cell growth • regulation of molecular function • endosomal transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55004	66508
Ensembl	ENSG00000149357	ENSMUSG00000030842
UniProt	Q6IAA8	Q9CQ22
RefSeq (mRNA)	NM_017907	NM_025605
RefSeq (protein)	NP_060377	NP_079881
Location (UCSC)	Chr 11: 72.09 – 72.1 Mb	Chr 7: 101.91 – 101.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000149357 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030842 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1". Retrieved 2018-10-01.

Further reading

• Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M (March 2009). "The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes". EMBO J. 28 (5): 477–89. doi:10.1038/emboj.2008.308. PMC 2657578. PMID 19177150.
• Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M (October 2009). "A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion". J. Biol. Chem. 284 (40): 27315–26. doi:10.1074/jbc.M109.041400. PMC 2785659. PMID 19654316.
• Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (April 2010). "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids". Cell. 141 (2): 290–303. doi:10.1016/j.cell.2010.02.024. PMC 3024592. PMID 20381137.
• Hoshino D, Koshikawa N, Seiki M (January 2011). "A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC". J. Biol. Chem. 286 (4): 3139–48. doi:10.1074/jbc.M110.159715. PMC 3024806. PMID 21087931.
• Malek M, Guillaumot P, Huber AL, Lebeau J, Pétrilli V, Kfoury A, Mikaelian I, Renno T, Manié SN (April 2012). "LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation". Cell Death Dis. 3 (4): e300. doi:10.1038/cddis.2012.39. PMC 3358017. PMID 22513874.
• Zada S, Noh HS, Baek SM, Ha JH, Hahm JR, Kim DR (November 2015). "Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation". Cell Biol. Int. 39 (11): 1242–50. doi:10.1002/cbin.10497. PMID 26032166.
• Wang L, Skotland T, Berge V, Sandvig K, Llorente A (February 2017). "Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation". Eur J Pharm Sci. 98: 80–85. doi:10.1016/j.ejps.2016.09.023. PMID 27664330.
• Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J (April 2017). "Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling". Mol. Cell. Proteomics. 16 (4): 594–607. doi:10.1074/mcp.M116.064543. PMC 5383781. PMID 28174230.
• de Araujo MEG, Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K (October 2017). "Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling". Science. 358 (6361): 377–381. doi:10.1126/science.aao1583. PMID 28935770.