L1TD1

LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers. [3] [4] [5] [6]

L1TD1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LR6, 3SOO
Identifiers
Aliases	L1TD1, ECAT11, LINE-1 type transposase domain containing 1, LINE1 type transposase domain containing 1
External IDs	HomoloGene: 136289 GeneCards: L1TD1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 62,194,849 bp[1] End 62,212,328 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • single-stranded RNA binding • GO:0001948 protein binding Cellular component • ribonucleoprotein Biological process • transposition, RNA-mediated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54596	n/a
Ensembl	ENSG00000240563	n/a
UniProt	Q5T7N2	n/a
RefSeq (mRNA)	NM_019079 NM_001164835	n/a
RefSeq (protein)	NP_001158307 NP_061952	n/a
Location (UCSC)	Chr 1: 62.19 – 62.21 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000240563 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.
4. Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.
5. Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.
6. Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996.

Further reading

• Mitsui K, Tokuzawa Y, Itoh H, et al. (2003). "The homeoprotein Nanog isrequired for maintenance of pluripotency in mouse epiblast and ES cells". Cell. 113 (5): 631–42. doi:10.1016/S0092-8674(03)00393-3. PMID 12787504.
• Cash HL, Tao L, Yuan JM, et al. (2012). "LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese". Int J Cancer. 130 (5): 1151–9. doi:10.1002/ijc.26098. PMC 3208798. PMID 21445976.