KDM8

Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene.[5]

KDM8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1
Identifiers
Aliases	KDM8, JMJD5, lysine demethylase 8
External IDs	OMIM: 611917 MGI: 1924285 HomoloGene: 49791 GeneCards: KDM8
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 27,203,495 bp[1] End 27,221,768 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 125,444,676 bp[2] End 125,462,269 bp[2]
Gene ontology Molecular function • dioxygenase activity • chromatin binding • oxidoreductase activity • metal ion binding • histone demethylase activity (H3-K36 specific) • histone demethylase activity • GO:0001948 protein binding • peptidase activity • hydrolase activity • aminopeptidase activity • endopeptidase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • methylated histone binding Cellular component • cell nucleus • nucleoplasm • cytosol • chromosome Biological process • regulation of transcription, DNA-templated • cell cycle • G2/M transition of mitotic cell cycle • oxidation-reduction process • positive regulation of transcription, DNA-templated • histone H3-K36 demethylation • transcription, DNA-templated • proteolysis • chromatin organization • protein destabilization • circadian regulation of gene expression • negative regulation of transcription, DNA-templated • rhythmic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79831	77035
Ensembl	ENSG00000155666	ENSMUSG00000030752
UniProt	Q8N371	Q9CXT6
RefSeq (mRNA)	NM_001145348 NM_024773	NM_029842
RefSeq (protein)	NP_001138820 NP_079049	NP_084118
Location (UCSC)	Chr 16: 27.2 – 27.22 Mb	Chr 7: 125.44 – 125.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.

References

1. GRCh38: Ensembl release 89: ENSG00000155666 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030752 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Lysine demethylase 8". Retrieved 2016-04-09.

Further reading

• Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG (2006). "Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice". EMBO J. 25 (14): 3422–31. doi:10.1038/sj.emboj.7601215. PMC 1523184. PMID 16858412.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.