INTS3

Integrator complex subunit 3 is a protein that in humans is encoded by the INTS3 gene.[5][6]

INTS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OWT, 4OWW, 4OWX
Identifiers
Aliases	INTS3, C1orf193, C1orf60, INT3, SOSS-A, SOSSA, integrator complex subunit 3
External IDs	OMIM: 611347 MGI: 2140050 HomoloGene: 11309 GeneCards: INTS3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,728,050 bp[1] End 153,774,808 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,391,388 bp[2] End 90,433,622 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integrator complex • SOSS complex • cell nucleus • nucleoplasm • nucleolus • cytoplasm Biological process • response to ionizing radiation • DNA repair • snRNA processing • cellular response to DNA damage stimulus • mitotic cell cycle checkpoint • snRNA transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	65123	229543
Ensembl	ENSG00000143624 ENSG00000262826	ENSMUSG00000027933
UniProt	Q68E01	Q7TPD0
RefSeq (mRNA)	NM_023015 NM_001324475	NM_145540 NM_178876
RefSeq (protein)	NP_001311404 NP_075391	NP_663515 NP_849207
Location (UCSC)	Chr 1: 153.73 – 153.77 Mb	Chr 3: 90.39 – 90.43 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000262826 GRCh38: Ensembl release 89: ENSG00000143624, ENSG00000262826 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027933 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
6. "Entrez Gene: INTS3 integrator complex subunit 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.