INPP4A

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.[5][6][7]

INPP4A
Identifiers
Aliases	INPP4A, INPP4, TVAS1, inositol polyphosphate-4-phosphatase type I A
External IDs	OMIM: 600916 MGI: 1931123 HomoloGene: 2871 GeneCards: INPP4A
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 98,444,854 bp[1] End 98,594,390 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 15.46 cM Start 37,299,865 bp[2] End 37,410,736 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity • GO:0001948 protein binding • hydrolase activity • inositol-3,4-bisphosphate 4-phosphatase activity • phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity • inositol-1,3,4-trisphosphate 4-phosphatase activity Cellular component • cytosol • cytoplasm Biological process • phosphatidylinositol biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • inositol phosphate metabolic process • signal transduction • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3631	269180
Ensembl	ENSG00000040933	ENSMUSG00000026113
UniProt	Q96PE3	Q9EPW0
RefSeq (mRNA)	NM_001134224 NM_001134225 NM_001566 NM_004027 NM_001351424 NM_001351425 NM_001351426 NM_001351427 NM_001351428 NM_001351429	NM_001290797 NM_001290798 NM_001290799 NM_030266 NM_172971 NM_001374629 NM_001374630
RefSeq (protein)	NP_001127696 NP_001127697 NP_001557 NP_004018 NP_001338353 NP_001338354 NP_001338355 NP_001338356 NP_001338357 NP_001338358	NP_001277726 NP_001277727 NP_001277728 NP_084542 NP_766559 NP_001361558 NP_001361559
Location (UCSC)	Chr 2: 98.44 – 98.59 Mb	Chr 1: 37.3 – 37.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000040933 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026113 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. doi:10.1074/jbc.270.27.16128. PMID 7608176.
6. Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. doi:10.1074/jbc.272.38.23859. PMID 9295334.
7. "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".

Further reading

• Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
• Norris FA, Atkins RC, Majerus PW (1997). "Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets". J. Biol. Chem. 272 (17): 10987–9. doi:10.1074/jbc.272.17.10987. PMID 9110986.
• Munday AD, Norris FA, Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3640–5. doi:10.1073/pnas.96.7.3640. PMC 22347. PMID 10097090.
• Joseph RE, Walker J, Norris FA (2000). "Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 276–7. doi:10.1159/000015448. PMID 10702694.
• Shearn CT, Walker J, Norris FA (2001). "Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene". Biochem. Biophys. Res. Commun. 286 (1): 119–25. doi:10.1006/bbrc.2001.5331. PMID 11485317.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ivetac I, Munday AD, Kisseleva MV, et al. (2005). "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane". Mol. Biol. Cell. 16 (5): 2218–33. doi:10.1091/mbc.E04-09-0799. PMC 1087230. PMID 15716355.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.