IL12A

Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene.[5]

IL12A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL12A, CLMF, IL-12A, NFSK, NKSF1, P35, interleukin 12A
External IDsOMIM: 161560 MGI: 96539 HomoloGene: 681 GeneCards: IL12A
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q25.33Start159,988,835 bp[1]
End159,996,019 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

3592

16159

Ensembl

ENSG00000168811

ENSMUSG00000027776

UniProt

P29459

P43431

RefSeq (mRNA)

NM_000882
NM_001354582
NM_001354583

NM_001159424
NM_008351

RefSeq (protein)

NP_000873
NP_001341511
NP_001341512

NP_001152896
NP_032377

Location (UCSC)Chr 3: 159.99 – 160 MbChr 3: 68.69 – 68.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of interferon gamma (INF-γ), and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000168811 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027776 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM (May 1991). "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells". J Immunol. 146 (9): 3074–81. PMID 1673147.
  6. "Entrez Gene: IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)".

Further reading


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