IFI6

Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.[3]

IFI6
Identifiers
Aliases	IFI6, 6-16, FAM14C, G1P3, IFI-6-16, IFI616, interferon alpha inducible protein 6
External IDs	OMIM: 147572 HomoloGene: 49720 GeneCards: IFI6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 27,666,064 bp[1] End 27,672,198 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • cell membrane • membrane • mitochondrion Biological process • negative regulation of mitochondrial depolarization • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • type I interferon signaling pathway • immune response • release of cytochrome c from mitochondria Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2537	n/a
Ensembl	ENSG00000126709	n/a
UniProt	P09912	n/a
RefSeq (mRNA)	NM_022873 NM_002038 NM_022872	n/a
RefSeq (protein)	NP_002029 NP_075010 NP_075011	n/a
Location (UCSC)	Chr 1: 27.67 – 27.67 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A mini-satellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.[3]

References

1. GRCh38: Ensembl release 89: ENSG00000126709 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: IFI6 interferon, alpha-inducible protein 6".

Further reading

• Itzhaki JE, Barnett MA, MacCarthy AB, et al. (1993). "Targeted breakage of a human chromosome mediated by cloned human telomeric DNA". Nat. Genet. 2 (4): 283–7. doi:10.1038/ng1292-283. PMID 1303280.
• Clauss IM, Wathelet MG, Szpirer J, et al. (1990). "Chromosomal localization of two human genes inducible by interferons, double-stranded RNA, and viruses". Cytogenet. Cell Genet. 53 (2–3): 166–8. doi:10.1159/000132920. PMID 1695131.
• Itzhaki JE, Porter AC (1991). "Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone". Nucleic Acids Res. 19 (14): 3835–42. doi:10.1093/nar/19.14.3835. PMC 328471. PMID 1713665.
• Kelly JM, Porter AC, Chernajovsky Y, et al. (1986). "Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells". EMBO J. 5 (7): 1601–6. PMC 1166985. PMID 3017706.
• Porter AC, Chernajovsky Y, Dale TC, et al. (1988). "Interferon response element of the human gene 6-16". EMBO J. 7 (1): 85–92. PMC 454218. PMID 3359997.
• Friedman RL, Manly SP, McMahon M, et al. (1984). "Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells". Cell. 38 (3): 745–55. doi:10.1016/0092-8674(84)90270-8. PMID 6548414.
• Turri MG, Cuin KA, Porter AC (1995). "Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript". Nucleic Acids Res. 23 (11): 1854–61. doi:10.1093/nar/23.11.1854. PMC 306954. PMID 7596809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hofmann WA, Stojiljkovic L, Fuchsova B, et al. (2004). "Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II". Nat. Cell Biol. 6 (11): 1094–101. doi:10.1038/ncb1182. PMID 15502823.
• Tahara E, Tahara H, Kanno M, et al. (2005). "G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell". Cancer Immunol. Immunother. 54 (8): 729–40. doi:10.1007/s00262-004-0645-2. PMID 15685448.