IFI27

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.[3][4]

IFI27
Identifiers
Aliases	IFI27, FAM14D, ISG12, ISG12A, P27, interferon alpha inducible protein 27
External IDs	OMIM: 600009 HomoloGene: 128815 GeneCards: IFI27
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 94,104,836 bp[1] End 94,116,698 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA polymerase II activating transcription factor binding • lamin binding • molecular function • GO:0001948 protein binding • identical protein binding Cellular component • integral component of membrane • mitochondrial outer membrane • nuclear inner membrane • membrane • mitochondrion • nuclear envelope • mitochondrial membranes • cell nucleus • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • apoptotic signaling pathway • negative regulation of transcription from RNA polymerase II promoter • activation of cysteine-type endopeptidase activity involved in apoptotic process • type I interferon signaling pathway • regulation of protein export from nucleus • apoptotic process • proteasome-mediated ubiquitin-dependent protein catabolic process • modulation by host of viral genome replication • innate immune system • defense response to virus • protein K48-linked ubiquitination • extrinsic apoptotic signaling pathway • immune system process • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3429	n/a
Ensembl	ENSG00000165949 ENSG00000275214	n/a
UniProt	P40305	n/a
RefSeq (mRNA)	NM_005532 NM_001130080 NM_001288952 NM_001288954 NM_001288956 NM_001288957 NM_001288958 NM_001288959 NM_001288960 NM_001288995 NM_001366993 NM_001366994	n/a
RefSeq (protein)	NP_001123552 NP_001275881 NP_001275883 NP_001275885 NP_001275886 NP_001275887 NP_001275888 NP_001275889 NP_001275924 NP_005523 NP_001353922 NP_001353923	n/a
Location (UCSC)	Chr 14: 94.1 – 94.12 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. ENSG00000275214 GRCh38: Ensembl release 89: ENSG00000165949, ENSG00000275214 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Rasmussen UB, Wolf C, Mattei MG, Chenard MP, Bellocq JP, Chambon P, Rio MC, Basset P (Sep 1993). "Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma". Cancer Research. 53 (17): 4096–101. PMID 8358738.
4. "Entrez Gene: IFI27 interferon, alpha-inducible protein 27".

Further reading

• Taulés M, Rius E, Talaya D, López-Girona A, Bachs O, Agell N (Dec 1998). "Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1". The Journal of Biological Chemistry. 273 (50): 33279–86. doi:10.1074/jbc.273.50.33279. PMID 9837900.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Martensen PM, Søgaard TM, Gjermandsen IM, Buttenschøn HN, Rossing AB, Bonnevie-Nielsen V, Rosada C, Simonsen JL, Justesen J (Nov 2001). "The interferon alpha induced protein ISG12 is localized to the nuclear membrane". European Journal of Biochemistry / FEBS. 268 (22): 5947–54. doi:10.1046/j.0014-2956.2001.02545.x. PMID 11722583.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Smidt KC, Hansen LL, Søgaard TM, Petersen LK, Knudsen UB, Martensen PM (Jul 2003). "A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1638 (3): 227–34. doi:10.1016/s0925-4439(03)00087-5. PMID 12878323.
• Taguchi T, Kato Y, Baba Y, Nishimura G, Tanigaki Y, Horiuchi C, Mochimatsu I, Tsukuda M (Feb 2004). "Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas". Oncology Reports. 11 (2): 421–6. doi:10.3892/or.11.2.421. PMID 14719078.
• Parker N, Porter AC (Jan 2004). "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12". BMC Genomics. 5 (1): 8. doi:10.1186/1471-2164-5-8. PMC 343271. PMID 14728724.
• Namciu SJ, Friedman RD, Marsden MD, Sarausad LM, Jasoni CL, Fournier RE (Mar 2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mammalian Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Fjaerli HO, Bukholm G, Krog A, Skjaeret C, Holden M, Nakstad B (2007). "Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis". BMC Infectious Diseases. 6: 175. doi:10.1186/1471-2334-6-175. PMC 1713240. PMID 17166282.