Growth factor-like domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1mwp, 1owt, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma

Amyloid precursor N-terminal
	The GFLD region of amyloid precursor protein
Identifiers
Symbol	APP_CU_bd
Pfam	PF02177
InterPro	IPR008154
SMART	SM00006
SCOPe	1mwp / SUPFAM
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1mwp, 1owt, 2fjz, 2fk1, 2fk2, 2fk3, 2fkl, 2fma

A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member of the heparin-binding class of GFLDs and may itself have growth factor function, particularly in promoting neuronal development.

References

Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW (April 1999). "Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein". Nature Structural Biology. 6 (4): 327–31. doi:10.1038/7562. PMID 10201399.

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