GPHB5

Glycoprotein hormone beta-5 is a protein that in humans is encoded by the GPHB5 gene.[5]

GPHB5
Identifiers
Aliases	GPHB5, B5, GPB5, ZLUT1, glycoprotein hormone beta 5, glycoprotein hormone subunit beta 5
External IDs	OMIM: 609652 MGI: 2156540 HomoloGene: 18476 GeneCards: GPHB5
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.2 Start 63,312,835 bp[1] End 63,318,935 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 75,411,722 bp[2] End 75,416,781 bp[2]
Gene ontology Molecular function • hormone activity • thyrotropin-releasing hormone receptor binding • protein heterodimerization activity • GO:0001948 protein binding Cellular component • extracellular region • extracellular • cytoplasm Biological process • regulation of thyroid hormone mediated signaling pathway • cell-cell signaling • hormone-mediated signaling pathway • cell surface receptor signaling pathway • regulation of receptor activity • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	122876	217674
Ensembl	ENSG00000179600	ENSMUSG00000048982
UniProt	Q86YW7	Q812B2
RefSeq (mRNA)	NM_145171	NM_175644
RefSeq (protein)	NP_660154	NP_783575
Location (UCSC)	Chr 14: 63.31 – 63.32 Mb	Chr 12: 75.41 – 75.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM][5]

References

1. GRCh38: Ensembl release 89: ENSG00000179600 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048982 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPHB5 glycoprotein hormone beta 5".

Further reading

• Okada SL, Ellsworth JL, Durnam DM, et al. (2006). "A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor". Mol. Endocrinol. 20 (2): 414–25. doi:10.1210/me.2005-0270. PMID 16210345.
• Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5". Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5". Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/me.16.7.1538. PMID 12089349.
• Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.