GNA15

Guanine nucleotide-binding protein subunit alpha-15 is a protein that in humans is encoded by the GNA15 gene.[5][6][7] G₁₅α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction. It was also previously known as G₁₆α.[5]

GNA15
Identifiers
Aliases	GNA15, GNA16, G protein subunit alpha 15
External IDs	OMIM: 139314 MGI: 95770 HomoloGene: 1563 GeneCards: GNA15
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,136,033 bp[1] End 3,163,749 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,502,306 bp[2] End 81,524,225 bp[2]
Gene ontology Molecular function • guanyl nucleotide binding • nucleotide binding • GTP binding • metal ion binding • GTPase activity • G-protein beta/gamma-subunit complex binding • G-protein coupled receptor binding • signal transducer activity Cellular component • cell membrane • heterotrimeric G-protein complex Biological process • platelet activation • phospholipase C-activating G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway • phospholipase C-activating dopamine receptor signaling pathway • activation of phospholipase C activity • signal transduction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2769	14676
Ensembl	ENSG00000060558	ENSMUSG00000034792
UniProt	P30679	P30678
RefSeq (mRNA)	NM_002068	NM_010304
RefSeq (protein)	NP_002059	NP_034434
Location (UCSC)	Chr 19: 3.14 – 3.16 Mb	Chr 10: 81.5 – 81.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Gq alpha subunit
• Heterotrimeric G protein

References

1. GRCh38: Ensembl release 89: ENSG00000060558 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034792 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014.
6. "Entrez Gene: GNA15 G protein subunit alpha 15 [ Homo sapiens (human) ]". Retrieved 2019-07-25.
7. GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-15; GNA15 at OMIM. Retrieved JULY 25, 2019.