GMPPB

Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.[5]

GMPPB
Identifiers
Aliases	GMPPB, MDDGA14, MDDGB14, MDDGC14, GDP-mannose pyrophosphorylase B, LGMDR19
External IDs	OMIM: 615320 MGI: 2660880 HomoloGene: 5578 GeneCards: GMPPB
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,716,844 bp[1] End 49,723,951 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 108,049,242 bp[2] End 108,052,801 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • mannose-1-phosphate guanylyltransferase activity • nucleotide binding • nucleotidyltransferase activity • GTP binding • GO:0001948 protein binding Cellular component • cytoplasm Biological process • biosynthetic process • GDP-mannose biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29925	331026
Ensembl	ENSG00000173540	ENSMUSG00000070284
UniProt	Q9Y5P6	Q8BTZ7
RefSeq (mRNA)	NM_021971 NM_013334	NM_177910 NM_001357682
RefSeq (protein)	NP_037466 NP_068806	NP_808578 NP_001344611
Location (UCSC)	Chr 3: 49.72 – 49.72 Mb	Chr 9: 108.05 – 108.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. The gene encodes two transcript variants.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000173540 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070284 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GMPPB GDP-mannose pyrophosphorylase B".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ono T, Sekino-Suzuki N, Kikkawa Y, et al. (2003). "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons". J. Neurosci. 23 (13): 5887–96. doi:10.1523/JNEUROSCI.23-13-05887.2003. PMC 6741272. PMID 12843293.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Ning B, Elbein AD (2001). "Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins". Eur. J. Biochem. 267 (23): 6866–74. doi:10.1046/j.1432-1033.2000.01781.x. PMID 11082198.