GFM2

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. [5][6] Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.[7]

GFM2
Identifiers
AliasesGFM2, EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2
External IDsOMIM: 606544 MGI: 2444783 HomoloGene: 6238 GeneCards: GFM2
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q13.3Start74,721,206 bp[1]
End74,767,147 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84340

320806

Ensembl

ENSG00000164347

ENSMUSG00000021666

UniProt

Q969S9

Q8R2Q4

RefSeq (mRNA)

NM_001281302
NM_032380
NM_170681
NM_170691

NM_001146043
NM_001271463
NM_001271464
NM_001271465
NM_177266

RefSeq (protein)

NP_001268231
NP_115756
NP_733781
NP_733792
NP_733792.1

NP_001139515
NP_001258392
NP_001258393
NP_001258394
NP_796240

Location (UCSC)Chr 5: 74.72 – 74.77 MbChr 13: 97.14 – 97.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000164347 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021666 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030.
  6. "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
  7. Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.


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