GCM1

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.[5][6]

GCM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ODH
Identifiers
Aliases	GCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
External IDs	OMIM: 603715 MGI: 108045 HomoloGene: 2702 GeneCards: GCM1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 53,126,961 bp[1] End 53,148,841 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E1|9 43.49 cM Start 78,051,924 bp[2] End 78,065,624 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • histone deacetylase binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • transcription factor complex • cell nucleus Biological process • regulation of transcription, DNA-templated • anatomical structure morphogenesis • positive regulation of syncytium formation by plasma membrane fusion • transcription from RNA polymerase II promoter • transcription, DNA-templated • multicellular organism development • branching involved in labyrinthine layer morphogenesis • astrocyte fate commitment • positive regulation of transcription from RNA polymerase II promoter • gliogenesis • regulation of cell differentiation involved in embryonic placenta development • cell differentiation involved in embryonic placenta development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8521	14531
Ensembl	ENSG00000137270	ENSMUSG00000023333
UniProt	Q9NP62	P70348
RefSeq (mRNA)	NM_003643	NM_008103
RefSeq (protein)	NP_003634	NP_032129
Location (UCSC)	Chr 6: 53.13 – 53.15 Mb	Chr 9: 78.05 – 78.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137270 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023333 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Akiyama Y, Hosoya T, Poole AM, Hotta Y (Jan 1997). "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals". Proc Natl Acad Sci U S A. 93 (25): 14912–6. doi:10.1073/pnas.93.25.14912. PMC 26236. PMID 8962155.
6. "Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila)".

Further reading

• Yamada K, Ogawa H, Honda S, et al. (1999). "A GCM motif protein is involved in placenta-specific expression of human aromatase gene". J. Biol. Chem. 274 (45): 32279–86. doi:10.1074/jbc.274.45.32279. PMID 10542267.
• Nait-Oumesmar B, Copperman AB, Lazzarini RA (2000). "Placental expression and chromosomal localization of the human Gcm 1 gene". J. Histochem. Cytochem. 48 (7): 915–22. doi:10.1177/002215540004800704. PMID 10858268.
• Yamada K, Ogawa H, Tamiya G, et al. (2001). "Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene". Biochem. Biophys. Res. Commun. 278 (1): 134–9. doi:10.1006/bbrc.2000.3775. PMID 11071865.
• Yu C, Shen K, Lin M, et al. (2003). "GCMa regulates the syncytin-mediated trophoblastic fusion". J. Biol. Chem. 277 (51): 50062–8. doi:10.1074/jbc.M209316200. PMID 12397062.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Chen CP, Chen CY, Yang YC, et al. (2005). "Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia". Placenta. 25 (5): 413–21. doi:10.1016/j.placenta.2003.10.014. PMID 15081636.
• Baczyk D, Satkunaratnam A, Nait-Oumesmar B, et al. (2004). "Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta". Placenta. 25 (6): 553–9. doi:10.1016/j.placenta.2003.12.004. PMID 15135239.
• Schubert SW, Kardash E, Khan MA, et al. (2005). "Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2". J. Biol. Chem. 279 (48): 50358–65. doi:10.1074/jbc.M404587200. PMID 15385555.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang CS, Yu C, Chuang HC, et al. (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc.M413986200. PMID 15640526.
• Knerr I, Schubert SW, Wich C, et al. (2005). "Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions". FEBS Lett. 579 (18): 3991–8. doi:10.1016/j.febslet.2005.06.029. PMID 16004993.
• Chang CW, Chuang HC, Yu C, et al. (2005). "Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa". Mol. Cell. Biol. 25 (19): 8401–14. doi:10.1128/MCB.25.19.8401-8414.2005. PMC 1265739. PMID 16166624.
• Chuang HC, Chang CW, Chang GD, et al. (2006). "Histone deacetylase 3 binds to and regulates the GCMa transcription factor". Nucleic Acids Res. 34 (5): 1459–69. doi:10.1093/nar/gkl048. PMC 1401512. PMID 16528103.
• Fujito N, Samura O, Miharu N, et al. (2007). "Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia". Hiroshima J. Med. Sci. 55 (1): 9–15. PMID 16594548.
• Chou CC, Chang C, Liu JH, et al. (2007). "Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a." J. Biol. Chem. 282 (37): 27239–49. doi:10.1074/jbc.M700351200. PMID 17646165.