FTSJ3

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene.[5]

FTSJ3
Identifiers
Aliases	FTSJ3, EPCS3, SPB1, FtsJ homolog 3, FtsJ RNA methyltransferase homolog 3, FtsJ RNA 2'-O-methyltransferase 3
External IDs	OMIM: 618411 MGI: 1860295 HomoloGene: 5451 GeneCards: FTSJ3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,819,433 bp[1] End 63,830,012 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 68.89 cM Start 106,249,142 bp[2] End 106,256,079 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • rRNA methyltransferase activity • GO:0001948 protein binding • RNA binding • rRNA (uridine-2'-O-)-methyltransferase activity • rRNA (guanine) methyltransferase activity Cellular component • cell nucleus • nucleolus • preribosome, large subunit precursor • preribosome, small subunit precursor Biological process • rRNA processing • methylation • RNA methylation • ribosome biogenesis • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • rRNA methylation • enzyme-directed rRNA 2'-O-methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117246	56095
Ensembl	ENSG00000108592	ENSMUSG00000020706
UniProt	Q8IY81	Q9DBE9
RefSeq (mRNA)	NM_017647	NM_025310
RefSeq (protein)	NP_060117	NP_079586
Location (UCSC)	Chr 17: 63.82 – 63.83 Mb	Chr 11: 106.25 – 106.26 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000108592 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020706 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FTSJ3 FtsJ homolog 3 (E. coli)".

Further reading

• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.