FCF1

rRNA-processing protein FCF1 homolog is a protein that in humans is encoded by the FCF1 gene.[5][6]

FCF1
Identifiers
Aliases	FCF1, Bka, C14orf111, UTP24, CGI-35, FCF1 rRNA-processing protein, rRNA-processing protein
External IDs	MGI: 1920986 HomoloGene: 5706 GeneCards: FCF1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 74,713,144 bp[1] End 74,738,620 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 84,970,897 bp[2] End 84,983,303 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding Cellular component • small-subunit processome • nucleolus • cell nucleus • nucleoplasm Biological process • ribosome biogenesis • rRNA processing • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51077	73736
Ensembl	ENSG00000119616	ENSMUSG00000021243
UniProt	Q9Y324	Q9CTH6
RefSeq (mRNA)	NM_015962 NM_001318508	NM_028632
RefSeq (protein)	NP_001305437 NP_057046	NP_082908
Location (UCSC)	Chr 14: 74.71 – 74.74 Mb	Chr 12: 84.97 – 84.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000119616 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021243 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rempola B, Karkusiewicz I, Piekarska I, Rytka J (Jun 2006). "Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing". Biochem Biophys Res Commun. 346 (2): 546–54. doi:10.1016/j.bbrc.2006.05.140. PMID 16762320.
6. "Entrez Gene: FCF1 FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)".

Further reading

• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Wellenreuther R, Schupp I, Poustka A, et al. (2004). "SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones". BMC Genomics. 5: 36. doi:10.1186/1471-2164-5-36. PMC 436056. PMID 15198809.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.