FBXO28

F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene.[5][6]

FBXO28
Identifiers
Aliases	FBXO28, CENP-30, Fbx28, F-box protein 28
External IDs	OMIM: 609100 MGI: 1261890 HomoloGene: 9050 GeneCards: FBXO28
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.11 Start 224,114,111 bp[1] End 224,162,047 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H5|1 84.93 cM Start 182,313,102 bp[2] End 182,341,629 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23219	67948
Ensembl	ENSG00000143756	ENSMUSG00000047539
UniProt	Q9NVF7	Q8BIG4
RefSeq (mRNA)	NM_001136115 NM_015176	NM_175127
RefSeq (protein)	NP_001129587 NP_055991	NP_780336
Location (UCSC)	Chr 1: 224.11 – 224.16 Mb	Chr 1: 182.31 – 182.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000143756 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
6. "Entrez Gene: FBXO28 F-box protein 28".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.