Ets variant 3

Ets variant 3 is a protein that in humans is encoded by the ETV3 gene.[5]

ETV3
Identifiers
Aliases	ETV3, METS, PE-1, PE1, bA110J1.4, ETS variant 3, ETS variant transcription factor 3
External IDs	OMIM: 164873 MGI: 1350926 HomoloGene: 21085 GeneCards: ETV3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 157,121,191 bp[1] End 157,138,474 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 87,525,407 bp[2] End 87,540,156 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DEAD/H-box RNA helicase binding • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • molecular function • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • RNA polymerase II transcription repressor complex • nuclear chromatin • transcriptional repressor complex • cell nucleus Biological process • regulation of transcription from RNA polymerase II promoter • cell differentiation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • cellular response to granulocyte macrophage colony-stimulating factor stimulus • transcription, DNA-templated • negative regulation of cell proliferation • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2117	27049
Ensembl	ENSG00000117036	ENSMUSG00000003382
UniProt	P41162	Q8R4Z4
RefSeq (mRNA)	NM_001145312 NM_005240	NM_001083318 NM_001286844 NM_012051 NM_001359750
RefSeq (protein)	NP_001138784 NP_005231	NP_001076787 NP_001273773 NP_036181 NP_001346679
Location (UCSC)	Chr 1: 157.12 – 157.14 Mb	Chr 3: 87.53 – 87.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000117036 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003382 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ets variant 3".

Further reading

• Klemsz M, Hromas R, Raskind W, Bruno E, Hoffman R (March 1994). "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23". Genomics. 20 (2): 291–4. doi:10.1006/geno.1994.1169. PMID 8020980.
• Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (July 2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell Cycle. 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
• Anney RJ, Lasky-Su J, O'Dúshláine C, Kenny E, Neale BM, Mulligan A, Franke B, Zhou K, Chen W, Christiansen H, Arias-Vásquez A, Banaschewski T, Buitelaar J, Ebstein R, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen H, Asherson P, Faraone SV, Gill M (December 2008). "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (8): 1369–78. doi:10.1002/ajmg.b.30871. PMID 18951430.
• Sawka-Verhelle D, Escoubet-Lozach L, Fong AL, Hester KD, Herzig S, Lebrun P, Glass CK (April 2004). "PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation". The Journal of Biological Chemistry. 279 (17): 17772–84. doi:10.1074/jbc.M311991200. PMID 14754893.
• Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK (April 2002). "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation". Cell. 109 (2): 169–80. doi:10.1016/S0092-8674(02)00714-6. PMID 12007404.
• Mesquita B, Lopes P, Rodrigues A, Pereira D, Afonso M, Leal C, Henrique R, Lind GE, Jerónimo C, Lothe RA, Teixeira MR (February 2013). "Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes". Breast Cancer Research and Treatment. 138 (1): 37–45. doi:10.1007/s10549-013-2408-2. PMID 23329352.
• El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray PJ (December 2007). "Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of Immunology. 179 (11): 7215–9. doi:10.4049/jimmunol.179.11.7215. PMID 18025162.