Early versus Late Intervention Trial with Estradiol

The Early versus Late Intervention Trial with Estradiol (ELITE) was a large randomized controlled trial that assessed the timing hypothesis that menopausal hormone therapy in early but not late menopause would improve cardiovascular outcomes.[1][2]

References

Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW (April 2015). "Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis". Menopause. 22 (4): 391–401. doi:10.1097/GME.0000000000000343. PMC 4376597. PMID 25380275.
Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed JT, Sontakke SP (December 2018). "Sex differences in the vascular function and related mechanisms: role of 17β-estradiol". Am. J. Physiol. Heart Circ. Physiol. 315 (6): H1499–H1518. doi:10.1152/ajpheart.00194.2018. PMID 30192631.

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[pmid25380275-1] Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW (April 2015). "Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis". Menopause. 22 (4): 391–401. doi:10.1097/GME.0000000000000343. PMC 4376597. PMID 25380275.

[pmid30192631-2] Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed JT, Sontakke SP (December 2018). "Sex differences in the vascular function and related mechanisms: role of 17β-estradiol". Am. J. Physiol. Heart Circ. Physiol. 315 (6): H1499–H1518. doi:10.1152/ajpheart.00194.2018. PMID 30192631.