EMP1

Epithelial membrane protein 1 is a protein that in humans is encoded by the EMP1 gene.[5][6][7]

EMP1
Identifiers
Aliases	EMP1, CL-20, EMP-1, TMP, epithelial membrane protein 1
External IDs	OMIM: 602333 MGI: 107941 HomoloGene: 1088 GeneCards: EMP1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 13,196,723 bp[1] End 13,219,941 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 66.25 cM Start 135,362,545 bp[2] End 135,383,173 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell membrane • membrane • integral component of membrane Biological process • multicellular organism development • bleb assembly • cellular proliferation • cell death • epidermis development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2012	13730
Ensembl	ENSG00000134531	ENSMUSG00000030208
UniProt	P54849	P47801
RefSeq (mRNA)	NM_001423	NM_001288627 NM_001288628 NM_010128
RefSeq (protein)	NP_001414	NP_001275556 NP_001275557 NP_034258
Location (UCSC)	Chr 12: 13.2 – 13.22 Mb	Chr 6: 135.36 – 135.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000134531 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030208 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ben-Porath I, Benvenisty N (Feb 1997). "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins". Gene. 183 (1–2): 69–75. doi:10.1016/S0378-1119(96)00475-1. PMID 8996089.
6. Chen Y, Medvedev A, Ruzanov P, Marvin KW, Jetten AM (May 1997). "cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family". Genomics. 41 (1): 40–8. doi:10.1006/geno.1997.4524. PMID 9126480.
7. "Entrez Gene: EMP1 epithelial membrane protein 1".

Further reading

• Jain A, Tindell CA, Laux I, et al. (2005). "Epithelial membrane protein-1 is a biomarker of gefitinib resistance". Proc. Natl. Acad. Sci. U.S.A. 102 (33): 11858–63. doi:10.1073/pnas.0502113102. PMC 1187965. PMID 16087880.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang HT, Kong JP, Ding F, et al. (2003). "Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray". World J. Gastroenterol. 9 (3): 392–8. doi:10.3748/wjg.v9.i3.392. PMC 4621547. PMID 12632483.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang HT, Liu ZH, Wang XQ, Wu M (2003). "[Effect of EMP-1 gene on human esophageal cancer cell line]". AI Zheng. 21 (3): 229–32. PMID 12451984.
• Liehr T, Kuhlenbäumer G, Wulf P, et al. (1999). "Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3". Genomics. 58 (1): 106–8. doi:10.1006/geno.1999.5803. PMID 10331954.
• Schiemann S, Rückels M, Engelholm LH, et al. (1997). "Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family". Anticancer Res. 17 (1A): 13–20. PMID 9066625.
• Lobsiger CS, Magyar JP, Taylor V, et al. (1997). "Identification and characterization of a cDNA and the structural gene encoding the mouse epithelial membrane protein-1". Genomics. 36 (3): 379–87. doi:10.1006/geno.1996.0482. PMID 8884260.
• Ruegg CL, Wu HY, Fagnoni FF, et al. (1996). "B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain". J. Immunol. 157 (1): 72–80. PMID 8683158.
• Marvin KW, Fujimoto W, Jetten AM (1996). "Identification and characterization of a novel squamous cell-associated gene related to PMP22". J. Biol. Chem. 270 (48): 28910–6. doi:10.1074/jbc.270.48.28910. PMID 7499420.